TNF and RANKL mediate bone destruction in common bone diseases, including
osteoarthritis and RA. They activate NF-κB canonical signaling directly in osteoclast …

The NF-κB (nuclear factor κB) family of transcription factors are involved in a myriad of
activities, including the regulation of immune responses, maturation of immune cells …

There is increasing evidence that NF-κB is a major, if not the major transcription factor
regulating inflammation and immunity. While this implies that blocking NF-κB might be …

Osteoarthritis (OA), the most common form of arthritis, is a disabling degenerative joint
disease affecting synovial joints and is associated with cartilage destruction, inflammation of …

Nuclear factor (NF)-kB is a key player in the control of both innate and adaptive immunity. NF-
kB proteins are present in the cytoplasm in association with inhibitory proteins called …

The transcription factor NF-κB might be the Holy Grail of therapeutic targets for rheumatoid
arthritis (RA). It serves as a “master switch” for an inflammatory cascade that encompasses …

Muscle development, growth, and maintenance require an intricate and timely series of
events initiated through a multitude of signaling pathways. The very nature of skeletal …

Aging is associated with significant bone loss and delayed fracture healing. NF‐κB
activation is highly correlated with inflammatory‐associated bone diseases including …

Osteoarthritis (OA) can be a progressive, disabling disease, leading to diminished quality of
life, and, for over 500,000 individuals annually in the US, total joint replacement. The …

Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high
morbidity. It is predicted to be the single greatest cause of disability in the general population …