Activation of intracellular signaling pathways by growth factors is one of the major causes of
cancer development and progression. Recent studies have demonstrated that monomeric G …

Tumor cell invasion through the extracellular matrix is accompanied by the formation of
invadopodia, which are actin-rich protrusions at the adherent surface of cells at sites of …

Invasion of tumor cells is a key step in metastasis that depends largely on the ability of these
cells to degrade the extracellular matrix. Although we have showed that the GTPase ADP …

ADP-ribosylation factor 4 (ARF4) is a member of the Ras superfamily of small guanine
nucleotide-binding proteins. ARF4 is known to interact with the epidermal growth factor …

Tumor cell invasion is a coordinated process involving the formation of invadopodia and the
localized degradation of the extracellular matrix (ECM). The process of cell invasion is …

The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …

ADP-ribosylation factors (ARFs) are monomeric G proteins that regulate many cellular
processes such as reorganization of the actin cytoskeleton. We have previously shown that …

This study shows that the small GTP-binding protein ADP-ribosylation factor 6 (ARF6) is an
important regulator of tumor growth and metastasis. Using spontaneous melanoma tumor …

The ADP-ribosylation factors (ARFs) 1 and 6 are small GTP-binding proteins, highly
expressed and activated in several breast cancer cell lines and are associated with …

Metastatic capacities are fundamental features of tumor malignancy. ADP-ribosylation factor
(ARF) 1 has emerged as a key regulator of invasion in breast cancer cells. However, the …