The management of patients with sepsis, severe sepsis, or septic shock requires an
integrated approach combining the use of rigorous diagnostic measures and the rapid …

Objective: In 2003, critical care and infectious disease experts representing 11 international
organizations developed management guidelines for antimicrobial therapy for patients with …

Background: Sepsis is life-threatening organ dysfunction caused by a dysregulated host
response to infection. Early recognition and treatment are the cornerstones of management …

Every patient with sepsis and septic shock must be evaluated thoroughly at presentation
before the initiation of antibiotic therapy. However, in most situations, an abridged initial …

Introduction Sepsis remains a common problem in critically ill patients. Discussion
Considerable advances have been made in our understanding of the pathophysiology of …

Appropriate antibiotic therapy in patients with severe sepsis and septic shock should mean
prompt achievement and maintenance of optimal exposure at the infection site with broad …

Rationale: Several Surviving Sepsis Campaign Guidelines recommendations are
reevaluated. Objectives: To analyze the effectiveness of treatments recommended in the …

Background In severe sepsis, guidelines recommend de-escalating the empirical
antimicrobial treatment as soon as the microbiological results are available. We aimed to …

Sepsis is the systemic inflammatory response to infection [1]. Sepsis and its sequelae
represent progressive stages of the same illness in which a systemic response to an …

Objectives: To assess the use of antibiotic de-escalation in patients with hospital-acquired
severe sepsis in an academic setting. Design: We reviewed all episodes of severe sepsis …