Parasites of the Leishmania genus infect and survive within macrophages by inhibiting
several microbicidal molecules, such as nitric oxide and pro-inflammatory cytokines. In this …

Leishmaniasis is a global health problem that affects more than 2 billion people worldwide.
Recent advances in research have demonstrated critical roles for cytoplasmic sensors and …

Highlights•Leishmania infection triggers activation of NLRP3 inflammasome in
macrophages.•Inflammasome activation in macrophages restricts intracellular parasite …

The various symptomatic outcomes of cutaneous leishmaniasis relates to the type and
potency of its underlying inflammatory responses. Presence of the cytoplasmic Leishmania …

In visceral leishmaniasis, we found that the antileishmanial drug Amp B produces a higher
level of IL‐1β over the infected control. Moreover, administering anti‐IL‐1β antibody to …

Activation of the NLRP3 inflammasome by Leishmania parasites is critical for the outcome of
leishmaniasis, a disease that affects millions of people worldwide. We investigate the …

Parasites of the Leishmania genus are the causative agents of leishmaniasis in humans, a
disease that affects more than 12 million people worldwide. These parasites replicate …

Protozoan parasites of the genus Leishmania are the causative agents of Leishmaniasis, a
disease that can be lethal and affects 12 million people worldwide. Leishmania replicates …

Leishmaniasis is a major tropical disease that can present with cutaneous, mucocutaneous,
or visceral manifestation and affects millions of individuals, causing substantial morbidity …

In cutaneous leishmaniasis, Leishmania amazonensis activates macrophage double-
stranded, RNA-activated protein kinase R (PKR) to promote parasite growth. In our study …