Migraine is a debilitating disorder characterized by recurrent headache arising from
neurovascular dysfunction. Despite recent progress in migraine research, the exact …

The neuropeptide calcitonin gene-related peptide (CGRP) plays a key role in migraine.
However, a major challenge for studying CGRP actions is the lack of animal models for …

Background Circadian patterns of migraine attacks have been reported by patients but
remain understudied. In animal models, circadian phases are generally not taken into …

Migraine is a medical condition with a severe recursive headache. The activation of the
trigeminovascular system is an important mechanism. The neuropeptide calcitonin gene …

Calcitonin-gene-related peptide (CGRP) plays a key role in migraine pathophysiology and
more specifically in the mechanisms underlying peripheral and central sensitization. Here …

Migraine is a neurological disorder that is far more than just a bad headache. A hallmark of
migraine is altered sensory perception. A likely contributor to this altered perception is the …

Over the past 300 years, the migraine field has been dominated by two main theories—the
vascular theory and the central neuronal theory. The success of vasoconstrictors such as …

With the approval of calcitonin gene-related peptide (CGRP) and CGRP receptor
monoclonal antibodies by the Federal Drug Administration, a new era in the treatment of …

Background Chronic migraine is a common and highly disabling disorder. Functional MRI
has indicated that abnormal brain region activation is linked with chronic migraine. Drugs …

A bi-directional relationship between epilepsy and migraine has been widely reported in
epidemiological and clinical studies, but the mechanisms of interaction between these …