New approaches to malignant glioma are being actively investigated. Local drug delivery
directly to the site of the tumor is one novel approach that has been approved by the US FDA …

The controlled local delivery of antineoplastic agents by biodegradable polymers is a
technique that allows for exposure of tumor cells to therapeutic doses of an active agent for …

Contemporary treatment of malignant brain tumors has been hampered by problems with
drug delivery to the tumor bed. Inherent boundaries of the central nervous system, such as …

The blood brain barrier (BBB) and the systemic toxicity of conventional chemotherapy
present obstacles to the success of future blood-borne drug therapies of brain tumors. The …

Malignant gliomas are among the most devastating human cancers. The infiltrating nature of
these malignancies makes complete surgical resection nearly impossible. Conventional …

Background: Despite significant advances in neurosurgery, radiation therapy, and
chemotherapy, the prognosis for patients with malignant brain tumors remains dismal. In an …

We have developed a systematic approach for the discovery and evaluation of local
treatment strategies for brain tumors using polymers. We demonstrated the feasibility of …

Despite advances in diagnostic imaging and drug discovery, primary malignant brain tumors
remain fatal. Median survival for patients with the most severe forms is rarely past eight …

Intracranial controlled release polymers have been used for drug delivery to the brain,
bypassing the blood brain barrier (BBB). By understanding the rates and patterns of …

Purpose: Carboplatin has shown promise experimentally as an antineoplastic agent against
both primary central nervous system (CNS) tumors and several solid tumors that frequently …