Increased dendritic spine densities on cortical projection neurons in autism spectrum disorders

JJ Hutsler, H Zhang - Brain research, 2010 - Elsevier
Multiple types of indirect evidence have been used to support theories of altered cortical
connectivity in autism spectrum disorders (ASD). In other developmental disorders reduced …

Dendrite and spine modifications in autism and related neurodevelopmental disorders in patients and animal models

V Martínez‐Cerdeño - Developmental neurobiology, 2017 - Wiley Online Library
Dendrites and spines are the main neuronal structures receiving input from other neurons
and glial cells. Dendritic and spine number, size, and morphology are some of the crucial …

Circuit-specific intracortical hyperconnectivity in mice with deletion of the autism-associated Met receptor tyrosine kinase

S Qiu, CT Anderson, P Levitt… - Journal of …, 2011 - Soc Neuroscience
Local hyperconnectivity in the neocortex is a hypothesized pathophysiological state in
autism spectrum disorder (ASD). MET, a receptor tyrosine kinase that regulates dendrite and …

Decreased frontal gyrification correlates with altered connectivity in children with autism

M Schaer, MC Ottet, E Scariati, D Dukes… - Frontiers in human …, 2013 - frontiersin.org
The structural correlates of functional dysconnectivity in autism spectrum disorders (ASD)
have been seldom explored, despite the fact that altered functional connectivity is one of the …

Enhanced synapse remodelling as a common phenotype in mouse models of autism

M Isshiki, S Tanaka, T Kuriu, K Tabuchi… - Nature …, 2014 - nature.com
Developmental deficits in neuronal connectivity are considered to be present in patients with
autism spectrum disorders (ASDs). Here we examine this possibility by using in vivo spine …

Dendritic spine actin cytoskeleton in autism spectrum disorder

M Joensuu, V Lanoue, P Hotulainen - Progress in Neuro …, 2018 - Elsevier
Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses. Changes in the shape and size of dendritic …

Changes in prefrontal axons may disrupt the network in autism

B Zikopoulos, H Barbas - Journal of Neuroscience, 2010 - Soc Neuroscience
Neural communication is disrupted in autism by unknown mechanisms. Here, we examined
whether in autism there are changes in axons, which are the conduit for neural …

Anatomical differences in the mirror neuron system and social cognition network in autism

N Hadjikhani, RM Joseph, J Snyder… - Cerebral …, 2006 - academic.oup.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with impaired
social and emotional skills, the anatomical substrate of which is still unknown. In this study …

Neuronal and glial cell number is altered in a cortical layer-specific manner in autism

C Falcone, NY Mevises, T Hong, B Dufour, X Chen… - …, 2021 - journals.sagepub.com
Autism spectrum disorder is a neurodevelopmental condition characterized by impaired
social communication and repetitive behaviors. Changes in the number of specific cell types …

Dendritic spine dysgenesis in autism related disorders

M Phillips, L Pozzo-Miller - Neuroscience letters, 2015 - Elsevier
The activity-dependent structural and functional plasticity of dendritic spines has led to the
long-standing belief that these neuronal compartments are the subcellular sites of learning …