Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …

Human histocompatibility leukocyte antigen (HLA)-DM is a facilitator of antigen presentation
via major histocompatibility complex (MHC) class II molecules. In the absence of HLA-DM …

Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …

The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has
recently been shown to play a central role in the class II-associated antigen presentation …

Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …

Loading of classical major histocompatibility complex (MHC) class II molecules with antigen-
derived peptides is fast, efficient and highly selective in vivo, quite in contrast to in vitro …

HLA-DM catalyzes the release of invariant chain fragments from newly synthesized major
histocompatibility complex (MHC) class II molecules, stabilizes empty class II molecules, and …

Major histocompatibllity complex (MHC) class II molecules bind antigenic peptides rapidly
after biosynthesis in antigen-presenting cells (APCs). By contrast, the rate of peptide binding …

The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …

HLA-DR molecules associated with class II—associated invariant chain peptides (CLIP) are
generated in vivo as an intermediate in class II maturation. Such complexes can be …