Editing of the HLA‐DR‐peptide repertoire by HLA‐DM.
H Kropshofer, AB Vogt, G Moldenhauer… - The EMBO …, 1996 - embopress.org
Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …
Human histocompatibility leukocyte antigen (HLA)-DM edits peptides presented by HLA-DR according to their ligand binding motifs.
SM van Ham, U Grüneberg, G Malcherek… - The Journal of …, 1996 - rupress.org
Human histocompatibility leukocyte antigen (HLA)-DM is a facilitator of antigen presentation
via major histocompatibility complex (MHC) class II molecules. In the absence of HLA-DM …
via major histocompatibility complex (MHC) class II molecules. In the absence of HLA-DM …
HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
LK Denzin, C Hammond, P Cresswell - The Journal of experimental …, 1996 - rupress.org
Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …
expression accumulate class II molecules associated with residual invariant (I) chain …
Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.
AB Vogt, H Kropshofer… - Proceedings of the …, 1996 - National Acad Sciences
The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has
recently been shown to play a central role in the class II-associated antigen presentation …
recently been shown to play a central role in the class II-associated antigen presentation …
HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading
SM Van Ham, EPM Tjin, BF Lillemeier, U Grüneberg… - Current biology, 1997 - cell.com
Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …
How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?
H Kropshofer, GJ Hämmerling, AB Vogt - Immunology Today, 1997 - cell.com
Loading of classical major histocompatibility complex (MHC) class II molecules with antigen-
derived peptides is fast, efficient and highly selective in vivo, quite in contrast to in vitro …
derived peptides is fast, efficient and highly selective in vivo, quite in contrast to in vitro …
Secondary structure composition and pH-dependent conformational changes of soluble recombinant HLA-DM
R Busch, Z Reich, DM Zaller, V Sloan… - Journal of Biological …, 1998 - ASBMB
HLA-DM catalyzes the release of invariant chain fragments from newly synthesized major
histocompatibility complex (MHC) class II molecules, stabilizes empty class II molecules, and …
histocompatibility complex (MHC) class II molecules, stabilizes empty class II molecules, and …
DM enhances peptide binding to class II MHC by release of invariant chain-derived peptide
MA Sherman, DA Weber, PE Jensen - Immunity, 1995 - cell.com
Major histocompatibllity complex (MHC) class II molecules bind antigenic peptides rapidly
after biosynthesis in antigen-presenting cells (APCs). By contrast, the rate of peptide binding …
after biosynthesis in antigen-presenting cells (APCs). By contrast, the rate of peptide binding …
Association between HLA-DM and HLA-DR in vivo
F Sanderson, C Thomas, J Neefjes, J Trowsdale - Immunity, 1996 - cell.com
The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …
In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
RR Avva, P Cresswell - Immunity, 1994 - cell.com
HLA-DR molecules associated with class II—associated invariant chain peptides (CLIP) are
generated in vivo as an intermediate in class II maturation. Such complexes can be …
generated in vivo as an intermediate in class II maturation. Such complexes can be …