Here we review the mechanisms that determine projection neuron identity during cortical
development. Pyramidal neurons in the mammalian cerebral cortex can be classified into …

The chromatin-remodeling protein Satb2 plays a role in the generation of distinct subtypes of
neocortical pyramidal neurons. Previous studies have shown that Satb2 is required for …

Pyramidal neurons in the deep layers of the cerebral cortex can be classified into two major
classes: callosal projection neurons and long-range subcortical neurons. We and others …

Generation of distinct cortical projection neuron subtypes during development relies in part
on repression of alternative neuron identities. It was reported that the special AT-rich …

Satb2 is a DNA-binding protein that regulates chromatin organization and gene expression.
In the developing brain, Satb2 is expressed in cortical neurons that extend axons across the …

During cortical development, the identity of major classes of long-distance projection
neurons is established by the expression of molecular determinants, which become …

Pyramidal neurons of the neocortex can be subdivided into two major groups: deep-(DL)
and upper-layer (UL) neurons. Here we report that the expression of the AT-rich DNA …

The acquisition of distinct neuronal fates is fundamental for the function of the cerebral
cortex. We find that the development of subcerebral projections from layer 5 neurons in the …

Neurons within each layer in the mammalian cortex have stereotypic projections. Four
genes—Fezf2, Ctip2, Tbr1, and Satb2—regulate these projection identities. These genes …

Satb1 is a first cell‐type‐specific transcription factor of a novel type that functions as a
regulator of the transcription of large chromatin domains. We identified a close homologue of …