Smart Conditioning with Venetoclax-Enhanced Sequential FLAMSA+ RIC in Patients with High-Risk Myeloid Malignancies
F Schulz, P Jäger, J Tischer, A Fraccaroli, G Bug… - Cancers, 2024 - mdpi.com
Simple Summary Allogeneic stem cell transplantation (aHSCT) is the only potentially
curative treatment option for patients with high-risk myeloid malignancies. Depending on the …
curative treatment option for patients with high-risk myeloid malignancies. Depending on the …
[HTML][HTML] A phase 1 dose-escalation study of adding venetoclax to a reduced intensity conditioning (RIC) regimen prior to allogeneic hematopoietic cell transplantation …
Background: Patients (pts) with myeloid malignancies characterized by high risk mutations
or cytogenetics who undergo allogeneic hematopoietic cell transplantation (HCT) have poor …
or cytogenetics who undergo allogeneic hematopoietic cell transplantation (HCT) have poor …
Conditioning with fludarabine and treosulfan compared to FLAMSA-RIC in allogeneic stem cell transplantation for myeloid malignancies: a retrospective single-center …
K Braitsch, A Schwarz, K Koch, M Hubbuch… - Annals of …, 2022 - Springer
Reduced intensity conditioning (RIC) and reduced toxicity conditioning (RTC) regimens
enable allogeneic hematopoietic stem cell transplantation (alloSCT) to more patients due to …
enable allogeneic hematopoietic stem cell transplantation (alloSCT) to more patients due to …
FLAMSA-RIC for stem cell transplantation in patients with acute myeloid leukemia and myelodysplastic syndromes: a systematic review and meta-analysis
W Owattanapanich, P Ungprasert, V Wais… - Journal of clinical …, 2019 - mdpi.com
Reduced-intensity conditioning (RIC) regimens are established options for hematopoietic
stem cell transplantation (HSCT) for patients with acute myeloid leukemia (AML) and …
stem cell transplantation (HSCT) for patients with acute myeloid leukemia (AML) and …
Similar outcome after allogeneic stem cell transplantation with a modified FLAMSA conditioning protocol substituting 4 Gy TBI with treosulfan in an elderly population …
U Holtick, M Herling, N Pflug, G Chakupurakal… - Annals of …, 2017 - Springer
The fludarabine, amsacrine, and cytarabine (FLAMSA)-reduced-intensity conditioning (RIC)
protocol has been described to be effective in patients with high-risk and refractory acute …
protocol has been described to be effective in patients with high-risk and refractory acute …
Adding venetoclax to fludarabine/busulfan RIC transplant for high-risk MDS and AML is feasible, safe, and active
JS Garcia, HT Kim, HM Murdock, CS Cutler… - Blood …, 2021 - ashpublications.org
Adding the selective BCL-2 inhibitor venetoclax to reduced-intensity conditioning
chemotherapy (fludarabine and busulfan [FluBu2]) may enhance antileukemic cytotoxicity …
chemotherapy (fludarabine and busulfan [FluBu2]) may enhance antileukemic cytotoxicity …
[HTML][HTML] Reduced relapse incidence with FLAMSA–RIC compared with Busulfan/Fludarabine for acute myelogenous leukemia patients in first or second complete …
T Heinicke, M Labopin, C Schmid, E Polge… - Biology of Blood and …, 2018 - Elsevier
Busulfan/fludarabine (BuFlu) is a widely used conditioning regimen for patients with myeloid
malignancies. The sequential FLAMSA (fludarabine+ Ara-C+ amsacrine chemotherapy) …
malignancies. The sequential FLAMSA (fludarabine+ Ara-C+ amsacrine chemotherapy) …
[HTML][HTML] FLAMSA-based reduced-intensity conditioning versus myeloablative conditioning in younger patients with relapsed/refractory acute myeloid leukemia with …
E Rodríguez-Arbolí, M Labopin, J Tischer… - Biology of Blood and …, 2020 - Elsevier
The use of myeloablative conditioning (MAC) in the setting of active relapsed/refractory
(R/R) acute myeloid leukemia (AML) has been hindered by high historical rates of …
(R/R) acute myeloid leukemia (AML) has been hindered by high historical rates of …
Sequential treatment with FLAG-IDA/treosulfan conditioning regimen for patients with active acute myeloid leukemia
L Shargian-Alon, O Wolach, U Rozovski, D Yahav… - Annals of …, 2020 - Springer
Sequential protocols combining salvage chemotherapy with reduced intensity conditioning
(RIC) and allogeneic hematopoietic cell transplantation (alloHCT) for high-risk acute …
(RIC) and allogeneic hematopoietic cell transplantation (alloHCT) for high-risk acute …
High antileukemic efficacy of an intermediate intensity conditioning regimen for allogeneic stem cell transplantation in patients with high-risk acute myeloid leukemia in …
C Schmid, M Schleuning, M Hentrich… - Bone marrow …, 2008 - nature.com
The goal of this analysis was to define the role of the moderate-intensity fludarabin Ara-C
amsacrin (FLAMSA)-reduced intensity conditioning (RIC) regimen for patients with high-risk …
amsacrin (FLAMSA)-reduced intensity conditioning (RIC) regimen for patients with high-risk …
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