Staphylococcal enterotoxins are prototype superantigens characterized by their ability to
bind to major histocompatibility complex (MHC) class II molecules and subsequently activate …

Bacterial superantigens, including the staphylococcal enterotoxins, are the most potent
activators of T cells known and have been suggested as a causative factor in Gram‐positive …

The X-ray structure of the superantigen staphylococcal enterotoxin H (SEH) has been
determined at 1.69 Å resolution. In this paper we present two structures of zinc-free SEH …

A comparative site-directed mutagenesis study of staphylococcal enterotoxins A and B was
undertaken to identify key amino-acid residues which govern interactions with major …

Staphylococcal enterotoxin B is a member of a family of toxins known as superantigens that
activate a large number of T-cells (up to 20%) by cross-linking MHC class II molecules with T …

Staphylococcal enterotoxins are a family of structurally related proteins that are produced by
Staphylococcus aureus. In addition to their role in the pathogenicity of food poisoning, these …

Background: Staphylococcus aureus enterotoxin C2 (SEC2) belongs to a family of proteins,
termed 'superantigens', that form complexes with class II MHC molecules enabling them to …

Superantigens are bacterial or viral proteins that elicit massive T cell activation through
simultaneous binding to major histocompatibility complex (MHC) class II and T cell …

The three-dimensional structure of staphylococcal enterotoxin B, which is both a toxin and a
super-antigen, has been determined to a resolution of 2.5 Å. The unusual main-chain fold …

Bacterial superantigens (SAgs) are potent activators of T lymphocytes and play a
pathophysiological role in Gram‐positive septic shock and food poisoning. To characterize …