Prolonged ischemia is known to damage the blood-brain barrier, causing an increase in
vascular permeability to proteins. We studied the time course of extravasation of …

Objective: Tracer constants (Ki) for blood-to-brain diffusion of sucrose were measured in the
rat to profile the time course of blood-brain barrier injury after temporary focal ischemia, and …

The blue azo dye, Evans blue, has a MW of 1.0 kDa. A notable property of Evans blue is its
propensity to bind serum albumin. The dye can, therefore, be used to measure the …

Ischemic stroke not only impairs neuronal function but also affects the cerebral vasculature
as indicated by loss of blood—brain barrier (BBB) integrity. Therefore, therapeutical …

Brain swelling is a serious complication associated with focal ischemia in stroke and severe
head injury. Experimentally, reperfusion following focal cerebral ischemia exacerbates the …

The respective influences of ischemic neuronal damage and infarction on the development
of abnormal blood-brain barrier (BBB) permeability and cerebral edema were evaluated in a …

Blood–brain barrier (BBB) disruption following ischemia–reperfusion is associated with such
devastating consequences as edema and hemorrhagic transformation. Although several …

In this study we explored if the secondary bioenergetic failure, which occurs a few hours
after recirculation, following transient middle cerebral artery occlusion (MCAO) in rats, is …

Background and Purpose—Blood–brain barrier opening during ischemia follows a biphasic
time course, may be partially reversible, and allows plasma constituents to enter brain and …

✓ A new model for establishing a successful and consistent arterial recirculation has been
devised following middle cerebral artery (MCA) occlusion in the rat. A snare ligature was …