In most experimental studies of the effects of ischemia on CNS electrical activity, the
ischemia produced has been total. The present experiments, however, were designed to …

Blood–brain barrier (BBB) leakage plays a key role in cerebral ischemia–reperfusion injury.
It is quite necessary to further explore the characteristic and mechanism of BBB leakage …

Abstract MIDDLE CEREBRAL ARTERY occlusion (MCAO) in rats produces an infarct of
varying size. We examined three factors that may influence this variability: animal weight …

Changes in morphology, behavior of the blood-brain barrier (BBB), regional cerebral blood
flow (rCBF), and local cerebral glucose utilization (LCGU) were assessed and correlated in …

The term blood-brain barrier (BBB) relates to the ability of cerebral vessels to hold back
hydrophilic and large molecules from entering the brain, thereby crucially contributing to …

Abstract Unilateral, transient (30, 60, and 120 minutes (min)) middle-cerebral-artery (MCA)
occlusion was induced via transorbital craniotomy in 11 waking subhuman primates. Local …

Correlations between changes in regional, cortical, cerebral blood flow (rCBF) and
histological changes in the corresponding brain regions were examined following middle …

Background and Purpose The clinical syndrome of transient ischemic attacks is
accompanied in a significant percentage of patients by brain lesions or neuroimaging …

Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

The present experiments were undertaken to define changes in tissue calcium metabolism
in focal and perifocal (“penumbral”) tissues following 2 h of transient middle cerebral artery …