We have recently proposed a new model for understanding how tumors evolve. To achieve
successful “Tumor‐Stroma Co‐Evolution”, cancer cells induce oxidative stress in adjacent …

We have recently proposed a new model for understanding how tumors evolve. To achieve
successful" Tumor-Stroma Co-Evolution", cancer cells induce oxidative stress in adjacent …

Cancer cells do not exist as pure homogeneous populations in vivo. Instead they are
embedded in “cancer cell nests” that are surrounded by stromal cells, especially cancer …

Significance: Here, we review certain recent advances in oxidative stress and tumor
metabolism, which are related to understanding the contributions of the microenvironment in …

The metabolic reconfiguration of tumor cells constitutes a pivotal aspect of tumor
proliferation and advancement. This study delves into two primary facets of tumor …

During tumor development, malignant cells rewire their metabolism to meet the biosynthetic
needs required to increase their biomass and to overcome their microenvironment …

A loss of stromal Cav-1 in the tumor fibroblast compartment is associated with early tumor
recurrence, lymph-node metastasis, and tamoxifen-resistance, resulting in poor clincical …

Previously, we proposed a new paradigm to explain the compartment-specific role of
autophagy in tumor metabolism. In this model, autophagy and mitochondrial dysfunction in …

Little is known about the mechanism (s) of arsenic-induced carcinogenesis. A study
published by Lee et al 1 in this issue of The American Journal of Pathology directly …

The process of tumorigenesis can be described by a series of molecular features, among
which alteration of cellular metabolism has recently emerged. This metabolic rewiring fulfills …