Introduction Sepsis is a complex inflammatory disorder believed to originate from an
infection by any types of microbes and/or their products. It is the leading cause of death in …

Background: Sepsis, a systemic inflammatory response to infection, resulting in organ failure
and death. Pathogenic microbial agents trigger cascades of events in sepsis by stimulating …

Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

Sepsis is a state of disrupted inflammatory homeostasis that is often initiated by infection.
The development and progression of sepsis is multi-factorial, and affects the cardiovascular …

In North America, approximately 700,000 cases of sepsis occur each year, with mortality
ranging between 30% and 50%. The American Journal of Pathology has featured numerous …

Pathophysiologic basis of sepsis: Considerations for future... : Critical Care Medicine
Pathophysiologic basis of sepsis: Considerations for future strategies of intervention : Critical …

Sepsis–the most common cause of death in hospitalized patients–affects over 18 million
people worldwide and has an expected 1% increase of incidence per year. Recent clinical …

The underlying principles of sepsis therapy have remained unchanged for decades. These
include: prompt institution of antimicrobial agents aimed at the inciting pathogen, source …

Sepsis, like cancer, is a disease concept that can be traced back to Greece during the time
of Hippocrates [1]. Whereas cancer described a condition of abnormal growth, sepsis was …