Sepsis is a life-threatening condition and a global disease burden. Today, the
heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated …

The clinical syndrome of sepsis encompasses a highly heterogeneous group of clinical
disorders, varying with respect to the site, bacteriology, and even presence of infection and …

Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of
death in critically ill patients. It is the most common condition with high mortality in intensive …

Objective: To discuss the difficulty in using the concept of sepsis for clinical trials and
propose new ways for designing future trials for severe infections. Design: Short position …

Infectious disease has been a leading cause of death in humans since the first recorded
tabulations. From Hippocrates and Galen, to Lister, Fleming and Semmelweiss, this article …

Sepsis, which is a highly heterogeneous syndrome, can result in death as a consequence of
a systemic inflammatory response syndrome. The activation and regulation of the immune …

Sepsis is a serious clinical problem involving complex mechanisms which requires better
understanding and insight. Animal models of sepsis have played a major role in providing …

Severe sepsis and septic shock are important causes of death in intensive care units.
Although our understanding of the pathogenesis of inflammation and sepsis has improved …

Recent advances in sepsis therapy exclusively involve improvements in supportive care,
while sepsis mortality rates remain disturbingly high at 30%. These persistently high sepsis …

Sepsis is a syndrome which is defined as a dysregulated host response to infection leading
to organ failure. Since it remains one of the leading causes of mortality worldwide, numerous …