Background Volume-controlled ventilation has been suggested to optimize lung deposition
during nebulization although promoting spontaneous ventilation is targeted to avoid …

Background The administration technique for inhaled drug delivery during invasive
ventilation remains debated. This study aimed to compare in vivo and in vitro the deposition …

Incremental gains in understanding the influence of various factors on aerosol delivery in
concert with technological advancements over the past 2 decades have fueled an ever …

Objective: to compare aerosol delivery from a standard (Bennett) nebulizer, a submicronic
(Ultravent) nebulizer, a metered dose inhaler (MDI) plus small holding chamber, and an MDI …

Pressurized metered-dose inhalers (pMDIs) and nebulizers are routinely employed for
aerosol delivery in mechanically ventilated patients. A significant proportion of the aerosol …

The delivery of aerosols to mechanically ventilated patients presents unique challenges and
differs from inhaled drug delivery in spontaneously breathing patients in several respects …

Among the devices employed for aerosol generation (metered-dose inhalers, nebulizers,
and dry powder inhalers) only metered-dose inhalers and nebulizers are routinely employed …

BACKGROUND: There is increasing use of therapeutic aerosols in patients undergoing
mechanical ventilation. Few studies have measured aerosol delivery to the lungs under …

Aerosol delivery via a mechanical ventilator remains unregulated with no standards for drug
delivery to intubated patients. Bench models predicting drug delivery have not been …

During the past decade the unprecedented improvements in technology for delivery of
inhaled drugs were matched by an equally impressive growth in clinical applications …