Cyclophosphamide (CP) is a widely used chemotherapeutic agent; however, its clinical
application is limited because of its multi-organ toxicity. Galangin (Gal) is a bioactive …

Background Acetaminophen (APAP) overdose-induced acute liver failure (ALF) is mainly
resulted from uncontrolled oxidative stress. Nuclear factor-erythroid 2-related factor 2 (Nrf2) …

This study examined the effects of genipin, isolated from Gardenia jasminoides Ellis, on d-
galactosamine (GalN) and lipopolysaccharide (LPS)-induced hepatic apoptosis and liver …

Alpinetin is the major active ingredient of Alpiniakatsumadai Hayata. As a kind of novel plant-
derived flavonoid, alpinetin has shown potent hepatoprotective effect against many liver …

Hepatotoxicity induced by cyclophosphamide (Cyclo) is a major concern in clinical practice.
This study was designed to investigate the possible cytoprotective effect of natural …

Liver cancer is a critical clinical condition with augmented malignancy, rapid progression,
and poor prognosis. Liver cancer often initiates as fibrosis, develops as cirrhosis, and results …

Forsythiae Fructus is known to have diuretic, anti-bacterial, and anti-inflammatory activities.
This study examined the hepatoprotective effects of pinoresinol, a lignan isolated from …

Cyclophosphamide is a potent anticancer agent. However its clinical use is restricted
because of its marked organ toxicity associated with increased oxidative stress and …

Liver diseases are one of the fatal disorders due to the vital role of the liver. Carbon
tetrachloride (CCl4) is the most perceived chemical substance utilized in developing models …

Apigenin, a flavonoid found in many plants, has various biological properties. We aimed to
investigate the anti-inflammatory and anti-oxidative activity of apigenin against carbon …