Abstract Background Tanshinone IIA (Tan), the main active component of Salvia miltiorrhiza,
has been demonstrated to have antioxidant activity. Acetaminophen (APAP), a widely used …

Acetaminophen (APAP)-induced hepatotoxicity is the main cause of drug-induced liver
injury. This study investigated the protection of baicalin and its aglycone baicalein against …

Ferulic acid (FA), a phenolic acid which is abundant in vegetables and fruits, has been
reported to exert anti-oxidative and anti-inflammatory activities. In the present study, the …

Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

Chlorogenic acid (CGA) is one of the most abundant dietary polyphenols, possessing well-
known antioxidant capacity. The present study is designed to observe the protection …

Acetaminophen (APAP) is a widely used analgesic and antipyretic drug that leads to severe
hepatotoxicity at excessive doses. Fucoidan, a sulfated polysaccharide derived from brown …

Chlorogenic acid (CGA) has been reported to prevent acetaminophen (AP)-induced
hepatotoxicity when mice were pre-administered orally with CGA for consecutive 7 days …

Acute liver failure (ALF) is a distinct clinical syndrome with high mortality and characterized
by metabolic derangements, neurological complication, and multiple failures. Flavonoids …

Exposure to organophosphorus insecticides causes several health problems to animals and
humans. Red beetroot (RBR) is rich in antioxidant ingredients and possesses a promising …

The liver is an important metabolic organ, and acute liver injury (ALI) is potentially lethal.
Itaconate, a metabolic intermediate from the tricarboxylic acid cycle, showed emerging anti …