Objective What mechanisms underlie the loss and recovery of consciousness after severe
brain injury? We sought to establish, in the largest cohort of patients with disorders of …

The concept of consciousness continues to defy definition and elude the grasp of
philosophical and scientific efforts to formulate a testable construct that maps to human …

Background Over the past 5 decades, advances in neuroimaging have yielded insights into
the pathophysiologic mechanisms that cause disorders of consciousness (DoC) in patients …

Without controlled studies and careful patient selection criteria it will not be possible to
evaluate the potential of therapeutic interventions in disorders of consciousness. There also …

Advances in neuroimaging techniques hold significant promise for improving understanding
of disorders of consciousness arising from severe brain injuries. We review neuroimaging …

Patients with disorders of consciousness (DoC) represent a group of severely brain-injured
patients with varying capacities for consciousness in terms of both wakefulness and …

Significant advances have been made in the behavioral assessment and clinical
management of disorders of consciousness (DOC). In addition, functional neuroimaging …

Abstract Background/Objective For patients with disorders of consciousness (DoC) and their
families, the search for new therapies has been a source of hope and frustration. Almost all …

Establishing an accurate diagnosis is crucial for patients with disorders of consciousness
(DoC) following a severe brain injury. The Coma Recovery Scale-Revised (CRS-R) is the …

Substantial progress has been made over the past two decades in detecting, predicting and
promoting recovery of consciousness in patients with disorders of consciousness (DoC) …