Studies of severe, monogenic forms of language disorders have revealed important insights
into the mechanisms that underpin language development and evolution. It is clear that …

Highlights•Rare variants disrupting speech, in genes like FOXP2, give insight into
neurobiology of key human traits.•Neural functions of FOXP2 are being studied in human …

The integration of language pathologies, genetics, brain imaging, molecular embryology,
and sequential gene expression, by means of DNA/RNA/proteomics, is a remarkable open …

The most well-described example of an inherited speech and language disorder is that
observed in the multigenerational KE family, caused by a heterozygous missense mutation …

Vocal learning underlies acquisition of both language in humans and vocal signals in some
avian taxa. These bird groups and humans exhibit convergent developmental phases and …

Human Genetics: The Evolving Story of FOXP2: Current Biology Skip to Main Content
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We previously discovered that mutations of the human FOXP2 gene cause a monogenic
communication disorder, primarily characterized by difficulties in learning to make …

The forkhead domain FOXP2 and FOXP1 transcription factors are implicated in several
cognitive disorders with language deficits, notably autism, and thus play a central role in …

The FOXP2 gene is important for the development of proper speech motor control in
humans. However, the role of the gene in general vocal behavior in other mammals …

Similarities between speech and birdsong make songbirds advantageous for investigating
the neurogenetics of learned vocal communication—a complex phenotype probably …