Mycobacterium tuberculosis drug resistance (DR) challenges effective tuberculosis disease
control. Current molecular tests examine limited numbers of mutations, and although whole …

Drug-resistant tuberculosis poses a persistent public health threat. The ReSeqTB platform is
a collaborative, curated knowledgebase, designed to standardize and aggregate global …

Whole-genome sequencing allows rapid detection of drug-resistant Mycobacterium
tuberculosis isolates. However, the availability of high-quality data linking quantitative …

Background Diagnosing drug-resistance remains an obstacle to the elimination of
tuberculosis. Phenotypic drug-susceptibility testing is slow and expensive, and commercial …

Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of
highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium …

Background A comprehensive understanding of the pre-existing genetic variation in genes
associated with antibiotic resistance in the Mycobacterium tuberculosis complex (MTBC) is …

Abstract Background The World Health Organization recommends drug-susceptibility testing
of Mycobacterium tuberculosis complex for all patients with tuberculosis to guide treatment …

Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major
threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction …

Whole genome sequencing (WGS) can provide insight into drug-resistance, transmission
chains and the identification of outbreaks, but data analysis remains an obstacle to its …

Abstract Drug-resistant TB (DR-TB) remains a significant challenge in TB treatment and
control programmes worldwide. Advances in sequencing technology have significantly …