Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

The abnormal deposition of proteins in and around neurons is a common pathological
feature of many neurodegenerative diseases. Among these pathological proteins, the …

Growing evidence over the past decade has led to the realization that many sporadic and
familial neurodegenerative diseases are characterized by distinct hallmark brain lesions …

Tau is a microtubule-associated protein whose misfolding, hyper-phosphorylation, loss of
normal function and toxic gain of function are linked to several neurodegenerative disorders …

BACKGROUND The microtubule-associated protein tau has been implicated in the
pathogenesis of Alzheimer's disease and a range of other neurodegenerative disorders …

Extracellular neuritic plaques composed of amyloid‑β (Aβ) protein and intracellular
neurofibrillary tangles containing phosphorylated tau protein are the two hallmark proteins of …

Alzheimer's disease (AD) is characterized by two major pathological lesions in the brain,
amyloid plaques and neurofibrillary tangles (NFTs) composed mainly of amyloid-β (Aβ) …

Alzheimer's disease (AD) is characterised by a progressive loss of cognitive functions.
Histopathologically, AD is defined by the presence of extracellular amyloid plaques …

Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Introduction• Pathological modifications of tau‐Tau phosphorylation‐Tau truncation‐NFTs
are not the primary toxic species• Tau turnover and possible deficits in Alzheimer disease• …