Molecular changes of epidermal growth factor receptor (EGFR) and KRAS and their impact on the clinical outcomes in surgically resected adenocarcinoma of the lung

YT Kim, T Kim, DS Lee, SJ Park, J Park, SJ Seo… - Lung Cancer, 2008 - Elsevier
Recent studies have reported that clinical response to epidermal growth factor receptor
(EGFR) inhibitors is associated with somatic changes of EGFR in the advanced stage of lung …
被引用次数：109 相关文章 所有 10 个版本
[PDF] researchgate.net

Impact of KRAS and EGFR Gene Mutations on Recurrence and Survival in Patients with Surgically Resected Lung Adenocarcinomas

M Sonobe, M Kobayashi, M Ishikawa, R Kikuchi… - Annals of surgical …, 2012 - Springer
Background Oncogenic gene mutations observed in lung adenocarcinomas, such as
epidermal growth factor receptor (EGFR) and KRAS, have some predictive value for …
被引用次数：61 相关文章 所有 9 个版本
[HTML] sciencedirect.com

[HTML][HTML] Prognostic implication of EGFR, KRAS, and TP53 gene mutations in a large cohort of Japanese patients with surgically treated lung adenocarcinoma

T Kosaka, Y Yatabe, R Onozato, H Kuwano… - Journal of Thoracic …, 2009 - Elsevier
Introduction: Although mutation of the epidermal growth factor receptor (EGFR) gene is
predictive for the response to EGFR-tyrosine kinase inhibitor, its prognostic impact for …
被引用次数：285 相关文章 所有 6 个版本

The mutations of the EGFR and K-ras genes in resected stage I lung adenocarcinoma and their clinical significance

T Ohba, G Toyokawa, T Kometani, K Nosaki, F Hirai… - Surgery today, 2014 - Springer
Purpose This study retrospectively assessed the mutations of the epidermal growth factor
receptor (EGFR) and K-ras genes and their clinical significance in patients with resected …
被引用次数：41 相关文章 所有 8 个版本

Impact of epidermal growth factor receptor and KRAS mutations on clinical outcome in resected non–small cell lung cancer patients

M Ragusa, J Vannucci, V Ludovini… - American journal of …, 2014 - journals.lww.com
Objectives: Surgery yields best results for non–small cell lung cancer (NSCLC) patients.
Epidermal growth factor receptor (EGFR) and its downstream factor Kirsten rat sarcoma viral …
被引用次数：28 相关文章 所有 8 个版本
[HTML] sciencedirect.com

[HTML][HTML] Prognostic and therapeutic implications of EGFR and KRAS mutations in resected lung adenocarcinoma

JL Marks, S Broderick, Q Zhou, D Chitale, AR Li… - Journal of thoracic …, 2008 - Elsevier
Background Somatic mutations in EGFR (exons 19 and 21) and KRAS (exon 2) are found in
lung adenocarcinomas and have potential prognostic value in patients with advanced …
被引用次数：287 相关文章 所有 9 个版本
[HTML] sciencedirect.com

[HTML][HTML] Distinct clinical course of EGFR-mutant resected lung cancers: results of testing of 1118 surgical specimens and effects of adjuvant gefitinib and erlotinib

SP D'Angelo, YY Janjigian, N Ahye, GJ Riely… - Journal of Thoracic …, 2012 - Elsevier
Background: EGFR and KRAS mutations are mutually exclusive and predict outcomes with
epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) treatment in patients …
被引用次数：208 相关文章 所有 9 个版本

Prognostic value of epidermal growth factor receptor mutations in resected lung adenocarcinomas

W Liu, L Zhao, Q Pang, Z Yuan, B Li, P Wang - Medical oncology, 2014 - Springer
The purpose of this study was to evaluate the association between epidermal growth factor
receptor (EGFR) mutations and prognosis in patients with completely resected lung …
被引用次数：59 相关文章 所有 7 个版本
[HTML] nih.gov

KRAS mutation is a significant prognostic factor in early-stage lung adenocarcinoma

K Kadota, CS Sima, ME Arcila, C Hedvat… - The American journal …, 2016 - journals.lww.com
The potential clinical impact of KRAS and epidermal growth factor receptor (EGFR)
mutations has been investigated in lung adenocarcinomas; however, their prognostic value …
被引用次数：58 相关文章 所有 7 个版本
[HTML] sciencedirect.com

[HTML][HTML] The presence of mutations in epidermal growth factor receptor gene is not a prognostic factor for long-term outcome after surgical resection of non–small-cell …

YT Kim, YW Seong, YJ Jung, YK Jeon, IK Park… - Journal of Thoracic …, 2013 - Elsevier
Background The presence of mutation in EGFR gene is known as a predictive marker for the
response to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) …
被引用次数：100 相关文章 所有 8 个版本