Abstract Carboxylesterase (CES) 1, CES2, and arylacetamide deacetylase (AADAC) are the
major drug hydrolases in humans, and they have different substrate preferences. Because …

The cynomolgus monkey is a nonhuman primate that is often used for pharmacokinetic and
toxicokinetic studies of new chemical entities. Species differences in drug metabolism are …

For drug development, species differences in drug-metabolism reactions present obstacles
for predicting pharmacokinetics in humans. We characterized the species differences in …

Carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the major enzymes
responsible for the hydrolysis of various clinical drugs. Our recent study demonstrated that …

In vitro inhibition studies on drug-metabolizing enzyme activity are useful for understanding
drug-drug interactions and for drug development. However, the profile of the inhibitory …

Differences in esterase expression among human, rhesus monkey, cynomolgus monkey,
dog, minipig, rabbit, rat, and mouse plasma were identified using native polyacrylamide gel …

Esterases catalyze the hydrolysis of therapeutic drugs containing esters or amides in their
structures. Human carboxylesterase (CES) and arylacetamide deacetylase (AADAC) are the …

Cynomolgus monkeys, used as an animal model to predict human pharmacokinetics,
occasionally show different oral absorption patterns to humans due to differences in their …

The age-associated alteration in expression levels of carboxylesterases (CESs) can affect
both intestinal and hepatic first-pass metabolism after oral administration of xenobiotic esters …

Carboxylesterase (CES) 1 and CES2 are two major hepatic hydrolases responsible for the
metabolism of numerous endogenous and exogenous compounds. In this study, age-and …