Mitochondrial dysfunction and oxidative stress have been implicated in cellular senescence,
apoptosis, aging and aging‐associated pathologies. Telomere shortening and genomic …

Reactive oxygen species (ROS) play important roles in aging, inflammation, and cancer.
Mitochondria are an important source of ROS; however, the spatiotemporal ROS events …

Aging is a biological process characterized by a progressive functional decline in tissues
and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat …

Cellular senescence is an irreversible cell arrest process, which is determined by a variety of
complicated mechanisms, including telomere attrition, mitochondrial dysfunction, metabolic …

Progressive DNA damage and mitochondrial decline are both considered to be prime
instigators of natural ageing. Traditionally, these two pathways have been viewed largely in …

Age and DNA repair deficiencies are strong risk factors for developing cancer. This is
reflected in the comorbidity of cancer with premature aging diseases associated with DNA …

The aging process deteriorates organs' function at different levels, causing its progressive
decline to resist stress, damage, and disease. In addition to alterations in metabolic control …

Most cancer cells express high levels of telomerase and proliferate indefinitely. In addition to
its telomere maintenance function, telomerase also has a pro-survival function resulting in …

Aging is a natural phenomenon characterized by progressive decline in tissue and organ
function leading to increased risk of disease and mortality. Among diverse factors that …

Telomerase is often re‐activated in human cancers and is widely used to immortalize cells in
culture. In addition to the maintenance of telomeres, telomerase has been implicated in cell …