[HTML][HTML] Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression

L Soreq, H Bird, W Mohamed, J Hardy - PLoS One, 2023 - journals.plos.org
Alzheimer's disease is the most common neurological disease worldwide. Unfortunately,
there are currently no effective treatment methods nor early detection methods. Furthermore …

[HTML][HTML] Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains

D Marques-Coelho, LCC Iohan… - npj Aging and …, 2021 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the
pathophysiological processes involved in AD onset and progression are still poorly …

[HTML][HTML] Revealing cell vulnerability in Alzheimer's disease by single-cell transcriptomics

CA Saura, A Deprada, MD Capilla-López… - Seminars in cell & …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that by affecting specific brain cell
types and regions cause severe pathological and functional changes in memory neural …

Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set

WS Liang, T Dunckley, TG Beach… - Physiological …, 2008 - journals.physiology.org
Alzheimer's Disease (AD) is the most widespread form of dementia during the later stages of
life. If improved therapeutics are not developed, the prevalence of AD will drastically …

[HTML][HTML] Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease

NA Twine, K Janitz, MR Wilkins, M Janitz - PloS one, 2011 - journals.plos.org
Recent studies strongly indicate that aberrations in the control of gene expression might
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …

Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease

S Morabito, E Miyoshi, N Michael… - Human molecular …, 2020 - academic.oup.com
Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …

[HTML][HTML] Cell type-specific potential pathogenic genes and functional pathways in Alzheimer's Disease

XL Wang, L Li - BMC neurology, 2021 - Springer
Background Alzheimer's disease (AD) is a pervasive age-related and highly heritable
neurodegenerative disorder but has no effective therapy. The complex cellular …

[HTML][HTML] Deciphering cellular transcriptional alterations in Alzheimer's disease brains

X Wang, M Allen, S Li, ZS Quicksall, TA Patel… - Molecular …, 2020 - Springer
Large-scale brain bulk-RNAseq studies identified molecular pathways implicated in
Alzheimer's disease (AD), however these findings can be confounded by cellular …

Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets

RA Neff, M Wang, S Vatansever, L Guo, C Ming… - Science …, 2021 - science.org
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …

[HTML][HTML] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease

JS Sadick, MR O'Dea, P Hasel, T Dykstra, A Faustin… - Neuron, 2022 - cell.com
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …