[HTML][HTML] Single-cell RNA sequencing analysis of human Alzheimer's disease brain samples reveals neuronal and glial specific cells differential expression
Alzheimer's disease is the most common neurological disease worldwide. Unfortunately,
there are currently no effective treatment methods nor early detection methods. Furthermore …
there are currently no effective treatment methods nor early detection methods. Furthermore …
[HTML][HTML] Differential transcript usage unravels gene expression alterations in Alzheimer's disease human brains
D Marques-Coelho, LCC Iohan… - npj Aging and …, 2021 - nature.com
Alzheimer's disease (AD) is the leading cause of dementia in aging individuals. Yet, the
pathophysiological processes involved in AD onset and progression are still poorly …
pathophysiological processes involved in AD onset and progression are still poorly …
[HTML][HTML] Revealing cell vulnerability in Alzheimer's disease by single-cell transcriptomics
CA Saura, A Deprada, MD Capilla-López… - Seminars in cell & …, 2023 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder that by affecting specific brain cell
types and regions cause severe pathological and functional changes in memory neural …
types and regions cause severe pathological and functional changes in memory neural …
Altered neuronal gene expression in brain regions differentially affected by Alzheimer's disease: a reference data set
WS Liang, T Dunckley, TG Beach… - Physiological …, 2008 - journals.physiology.org
Alzheimer's Disease (AD) is the most widespread form of dementia during the later stages of
life. If improved therapeutics are not developed, the prevalence of AD will drastically …
life. If improved therapeutics are not developed, the prevalence of AD will drastically …
[HTML][HTML] Whole transcriptome sequencing reveals gene expression and splicing differences in brain regions affected by Alzheimer's disease
Recent studies strongly indicate that aberrations in the control of gene expression might
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …
contribute to the initiation and progression of Alzheimer's disease (AD). In particular …
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease
Alzheimer's disease (AD) is a devastating neurological disorder characterized by changes in
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
cell-type proportions and consequently marked alterations of the transcriptome. Here we use …
[HTML][HTML] Cell type-specific potential pathogenic genes and functional pathways in Alzheimer's Disease
XL Wang, L Li - BMC neurology, 2021 - Springer
Background Alzheimer's disease (AD) is a pervasive age-related and highly heritable
neurodegenerative disorder but has no effective therapy. The complex cellular …
neurodegenerative disorder but has no effective therapy. The complex cellular …
[HTML][HTML] Deciphering cellular transcriptional alterations in Alzheimer's disease brains
Large-scale brain bulk-RNAseq studies identified molecular pathways implicated in
Alzheimer's disease (AD), however these findings can be confounded by cellular …
Alzheimer's disease (AD), however these findings can be confounded by cellular …
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Alzheimer's disease (AD), the most common form of dementia, is recognized as a
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
heterogeneous disease with diverse pathophysiologic mechanisms. In this study, we …
[HTML][HTML] Astrocytes and oligodendrocytes undergo subtype-specific transcriptional changes in Alzheimer's disease
Resolving glial contributions to Alzheimer's disease (AD) is necessary because changes in
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
neuronal function, such as reduced synaptic density, altered electrophysiological properties …
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