Understanding mechanisms by which glibenclamide stimulates insulin release is important,
particularly given recent promising treatment by glibenclamide of permanent neonatal …

Antidiabetic sulfonylureas and potassium channel openers affect the activity of the ATP-
regulated potassium channel (KATP channel) present in the plasma membrane of various …

Type 2 diabetes is a chronic metabolic derangement that results from defects in both insulin
action and secretion. New thiazolidinedione insulin sensitizers have been recently …

Physiologically, insulin secretion is subject to a dual, hierarchal control by triggering and
amplifying pathways. By closing ATP-sensitive K+ channels (KATP channels) in the plasma …

Pancreatic beta cells, unique cells that secrete insulin in response to an increase in glucose
levels, play a significant role in glucose homeostasis. Glucose-stimulated insulin secretion …

Long after the pioneering studies documenting the existence of insulin (year 1967) and
insulin receptor (year 1978) in brain, the last decade has witnessed extraordinary progress …

Current treatments for non-insulin dependent diabetes mellitus (NIDDM) remain far from
ideal. The universal finding of islet dysfunction characterised by the absence of first phase …

Abstract Type 2 diabetes (T2DM) is a chronic metabolic disorder. Impaired insulin secretion,
enhanced hepatic glucose production, and suppressed peripheral glucose use are the main …

Diabetes mellitus (DM) results from defects in insulin secretion (type 1) or insulin resistance
(type 2). Insulin is used to manage type 1 DM, and oral hypoglycemic agents are used to …

Abstract According to the World Health Organization, 422 million adults worldwide live with
diabetes mellitus (DM), a significant portion of whom have type 2 diabetes. The discovery of …