Diabetes Mellitus is by far one of the most propagated chronic diseases, affecting 150
million people worldwide. This affliction is caused by a malfunction of pancreatic endocrine …

The discovery of insulin in 1921 and the progress achieved in the ensuing century highlight
the promise and challenge of biochemically modifying the molecule to achieve optimization …

Aims/hypothesis. To characterise the effects of BPDZ 73 (7-chloro-3-isopropylamino-4 H-1,
2, 4-benzothiadiazine 1, 1-dioxide), a newly synthesised diazoxide analogue, on insulin …

The war against diabetes through the development of new drugs is an ongoing continuous
process to counter the alarming global increase in the prevalence of diabetes and its …

Insulin is a key anabolic hormone that plays a crucial role in growth, differentiation and
metabolism. Insulin action is initiated by the binding of the hormone to its tyrosine kinase cell …

Background: Insufficient insulin secretion is a core pathogenetic mechanism of diabetes
mellitus and therefore, insulin therapy remains the cornerstone of management. Over the …

Nateglinide and mitiglinide (glinides) are characterized as rapid-onset and short-acting
insulinotropic agents. Although both compounds do not have a sulfonylurea structure, it has …

The peptide hormone insulin is secreted from pancreatic β cells, binds to cell surface
receptors, and exerts a broad spectrum of anabolic effects in multiple tissues. In mediating …

Background: Insulin resistance alone does not result in the development of type 2 diabetes;
progressive dysfunction of pancreatic islet α and β cells, which results in inadequate control …

Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …