The peptide hormone insulin not only regulates metabolic pathways, but also proliferative
signaling pathways. Insulin regulates cell proliferation, protein synthesis and gene …

Glucose regulates pancreatic islet α-cell glucagon secretion directly by its metabolism to
generate ATP in α-cells, and indirectly via stimulation of paracrine release of β-cell secretory …

Type 2 diabetes primarily develops from pathogenic defects in the mechanisms of insulin
secretion and hepatic and peripheral insulin action. The consequent disruption of normal …

The MIN6 cell line derived from in vivo immortalized insulin‐secreting pancreatic β cells was
used to study the insulin‐releasing capacity and the cellular mode of action of S‐22068, a …

Insulin secretion from the β-cells of the endocrine pancreas is subject to a pot-pourri of
stimulatory, modulatory and inhibitory influences. β-Cell secretion is reduced or blocked by a …

The sulphonylureas act by triggering insulin release from the pancreatic β cell. A specific site
on the adenosine triphosphate (ATP)-sensitive potassium channels is occupied by …

Most patients with type 2 (non-insulin-dependent) diabetes mellitus require
pharmacotherapy, initially as monotherapy and subsequently in combination, as adjuncts to …

The treatment of type 1 diabetes mellitus consists of external replacement of the functions of
β cells in an attempt to achieve blood levels of glucose as close to the normal range as …

Sulfonylureas are widely used to treat type 2 diabetes because they stimulate insulin
secretion from pancreatic β-cells. They primarily act by binding to the SUR subunit of the …

All forms of diabetes have been treatable since insulin became medically available in 1921.
While insulin alone produces a substantial reduction in blood-glucose levels and is thus the …