Prolyl‐4‐hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …

Lung cancer is the leading cause of cancer-related deaths globally and is histologically
defined as either small cell lung cancer (SCLC) or non-small cell lung cancer (NSCLC), with …

Collagen is the main component of the extracellular matrix. Hydroxylation of proline residues
on collagen, catalyzed by collagen prolyl 4-hydroxylase (C-P4H), is essential for the stability …

Abstract P4HB and GRP78 are molecular chaperones involved in cellular response to ER
stress. They have been linked to cancer progression; however, their roles in hepatocellular …

The aims of this study were to investigate the expression of prolyl 4-hydroxylase subunit
alpha-1 (P4HA1) and its relationship with clinicopathological features in lung cancer (LC) …

Abstract Collagen prolyl 4-hydroxylase (P4H) expression and collagen hydroxylation in
cancer cells are necessary for breast cancer progression. Here, we show that P4H alpha 1 …

Prolyl 4-hydroxylase alpha subunit is the enzymic active site of prolyl 4-hydroxylase, which
is a critical enzyme to maintain the stability of newly synthesized collagens. The expression …

The aim of the present study was to investigate the role of prolyl 4-hydroxylase beta
polypeptide (P4HB) in the chemoresistance of liver cancer. Drug‑resistant liver cancer cell …

Background. Prolyl 3‐hydroxylase 1 (P3H1) is essential for human collagen synthesis. Here,
we investigated its relevance to multiple cancers, especially hepatocellular carcinoma …

The prolyl 3-hydroxylase family member 4 (P3H4)(alias SC65) is implicated in a variety of
physiological and pathological processes. However, little is known about the role of P3H4 in …