PH20 is a member of the human hyaluronidase family that degrades hyaluronan in the
extracellular matrix and controls tumor progression. Inhibition of DNA methyltransferases …

Protein methyltransferase SUV39H2 was reported to methylate histone H2AX at lysine 134
and enhance the formation of phosphorylated H2AX (γ-H2AX), which causes …

Background Polarization of microglia cells in the glioma microenvironment is closely related
to the malignant progression and invasion of gliomas. Prolyl 4-hydroxylase subunit α1 …

The antimicrobial peptide HPA3 shows anticancer activity in gastric cancer and leukaemia.
However, how HPA3 exerts its anticancer activity, as well as whether it also exhibits activity …

The pro-tumorigenic properties of heparanase are well documented and established. In
contrast, the role of heparanase 2 (Hpa2), a close homolog of heparanase, in cancer is not …

Abstract Protein phosphatase 4 (PP4) plays an indispensable regulatory part in the
development and malignant progression of multifarious tumors. Nevertheless, the function of …

Gastric cancer (GC) is a common tumor‐associated lethal disease, and invasiveness and
metastasis are primary challenges in its clinical treatment. Hypoxia microenvironment …

Abstract Background Methyltransferase 3 (METTL3)‐mediated N6‐methyladenosine (m6A)
RNA modification has been demonstrated to be a potential factor in promoting gastric cancer …

Hypoxia-inducible factor 1α (HIF1α) activation is profoundly implicated in the initiation and
progression of multiple malignant tumors. Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is …

The approval of poly (ADP-ribose) polymerase (PARP) inhibitor AZD2281 in 2014 marked
the successful establishment of the therapeutic strategy targeting homologous …