Two major pathways of penile carcinogenesis: HPV-induced penile cancers overexpress p16ink4a, HPV-negative cancers associated with dermatoses express p53 …

S Mannweiler, S Sygulla, E Winter… - Journal of the American …, 2013 - Elsevier
BACKGROUND: Penile squamous cell carcinomas (SCC) arise either through transforming
infections with human papillomavirus (HPV) or independent of HPV, often in the background …

Penile carcinogenesis in a low-incidence area: a clinicopathologic and molecular analysis of 115 invasive carcinomas with special emphasis on chronic inflammatory …

S Mannweiler, S Sygulla… - The American journal …, 2011 - journals.lww.com
Background Human papillomavirus (HPV) infections account worldwide for 50% of penile
cancers. The role of lichen sclerosus and lichen planus in penile carcinogenesis needs …

Human papillomavirus infection and immunohistochemical p16INK4a expression as predictors of outcome in penile squamous cell carcinomas

SM Bezerra, A Chaux, MW Ball, SF Faraj, E Munari… - Human pathology, 2015 - Elsevier
Approximately 50% of penile squamous cell carcinomas (SCC) are associated with high-risk
human papillomavirus (HR-HPV) infection. We evaluated the correlation of p16 INK4a …

Identification and genotyping of human papillomavirus in a Spanish cohort of penile squamous cell carcinomas: correlation with pathologic subtypes, p16INK4a …

C Ferrándiz-Pulido, E Masferrer, I De Torres… - Journal of the American …, 2013 - Elsevier
BACKGROUND: Penile squamous cell carcinoma (PSCC) is a tumor with a high metastatic
potential. In PSCC the attributable fraction to human papillomavirus (HPV) is not well …

Value of p16INK4a in the pathology of invasive penile squamous cell carcinomas: a report of 202 cases

AL Cubilla, B Lloveras, M Alejo, O Clavero… - The American journal …, 2011 - journals.lww.com
Background One third to one half of penile squamous cell carcinomas (SCCs) are related to
human papillomavirus (HPV) infection. Viral detection is usually carried out by polymerase …

Human papillomavirus‐associated increase in p16INK4A expression in penile lichen sclerosus and squamous cell carcinoma

DM Prowse, EN Ktori, D Chandrasekaran… - British Journal of …, 2008 - academic.oup.com
Summary Background Human papillomaviruses (HPVs) are sexually transmitted human
carcinogens that may play a role in the oncogenesis of penile cancer. Objectives To …

The role of histologic subtype, p16INK4a expression, and presence of human papillomavirus DNA in penile squamous cell carcinoma

J Steinestel, A Al Ghazal, A Arndt, TJ Schnoeller… - BMC cancer, 2015 - Springer
Background Up to 50% of penile squamous cell carcinomas (pSCC) develop in the context
of high-risk human papillomavirus (HR-HPV) infection. Most of these tumours have been …

Human papillomavirus, Epstein‐Barr virus, and methylation status of p16ink4a in penile cancer

LA Afonso, FN Carestiato, AA Ornellas… - Journal of medical …, 2017 - Wiley Online Library
Little is known about penile carcinogenesis. The aim of this study was to evaluate the
prevalence of HPV and EBV, and the methylation status of p16ink4a in penile cancer …

Clinical significance of p53 and p16ink4a status in a contemporary North American Penile Carcinoma Cohort

K Zargar-Shoshtari, PE Spiess, AE Berglund… - Clinical genitourinary …, 2016 - Elsevier
Background Because of the low incidence of penile carcinoma (PC), the value of p16 ink4a,
p53, and human papilloma virus (HPV) infection status in clinical practice remains unclear …

Human papillomavirus-16 is the predominant type etiologically involved in penile squamous cell carcinoma

DAM Heideman, T Waterboer, M Pawlita… - Journal of clinical …, 2007 - ascopubs.org
Purpose Human papillomavirus (HPV) infections are suggested to be involved in the
development of penile squamous cell carcinoma (SCC), but comprehensive studies to …