Glycol chitosan, a derivative of chitosan, can be hydrophobically modified by 5β-cholanic
acid to impart amphiphilic properties that enable the self-assembly into nanoparticles in …

Therapeutic proteins are often highly susceptible to enzymatic degradation, thus restricting
their in vivo stability. To overcome this limitation, delivery systems designed to promote …

Abstract Background Glycol chitosan nanoparticles (CNPs) have emerged as an effective
drug delivery system for cancer diagnosis and treatment. Although they have great …

To improve the in vivo tumor targeting characteristics of polymeric nanoparticles, three glycol
chitosan (GC-20 kDa, GC-100 kDa, and GC-250 kDa) derivatives with different molecular …

To make a tumor targeting nano-sized drug delivery system, biocompatible and
biodegradable glycol chitosan (Mw= 250 kDa) was modified with hydrophobic cholanic acid …

To evaluate the tumor targeting efficiency of self-assembled polymeric nanoparticles, four
glycol chitosan nanoparticles (CNPs) with different degrees of hydrophobic substitution were …

Glycol chitosan (GC) is the chitosan derivative that is capable of forming amphiphilic
nanoparticles upon structure modifications at the reactive functional amine group on the …

Polymeric nanoparticle-based carriers are promising agents for the targeted delivery of
therapeutics to the intracellular site of action. To optimize the efficacy in delivery, often the …

In this study, a new alternative of ionic crosslinked nanoparticles (NPs) based on chitosan
(C) and bovine serum albumin (A; BSA) was evaluated as drug delivery system for …

Herein, we elucidated the mechanisms and key factors for the tumor-targeting ability of
nanoparticles that presented high targeting efficiency for liver tumor. We used several …