Essential Role for Neutrophils but not Alveolar Macrophages at Early Time Points following Aspergillus fumigatus Infection

MM Mircescu, L Lipuma, N Van Rooijen… - The Journal of …, 2009 - academic.oup.com
Alveolar macrophages and neutrophils mediate innate immune defense against the
opportunistic fungal pathogen Aspergillus fumigatus and are believed to be essential for …

Innate lung defense during invasive aspergillosis: new mechanisms

JM Garth, C Steele - Journal of innate immunity, 2017 - karger.com
Invasive aspergillosis (IA) is one of the most difficult to treat and, consequently, one of the
most lethal fungal infections known to man. Continued use of immunosuppressive agents …

Aberrant tissue localization of fungus-specific CD4+ T cells in IL-10-deficient mice

A Rivera, N Collins, MT Stephan, L Lipuma… - The Journal of …, 2009 - journals.aai.org
Aspergillus fumigatus, a common environmental fungus, can cause lethal invasive infections
in immunocompromised hosts. In immunocompetent individuals, however, inhaled A …

When Aspergillus fumigatus Meets the Man

SSW Wong, JP Latgé - Current Progress in Medical Mycology, 2017 - Springer
Aspergillus fumigatus is one of the most ubiquitous opportunistic fungal pathogen, which
can cause life-threatening invasive pulmonary infections in immunocompromised …

The innate immune response to Aspergillus fumigatus at the alveolar surface

A Margalit, K Kavanagh - FEMS microbiology reviews, 2015 - academic.oup.com
Aspergillus fumigatus is an ubiquitous, saprophytic mould that forms and releases airborne
conidia which are inhaled by humans on a daily basis. When the immune system is …

Coevolution of TH1, TH2, and TH17 Responses during Repeated Pulmonary Exposure to Aspergillus fumigatus Conidia

BJ Murdock, AB Shreiner, RA McDonald… - Infection and …, 2011 - Am Soc Microbiol
Aspergillus fumigatus, a ubiquitous airborne fungus, can cause invasive infection in
immunocompromised individuals but also triggers allergic bronchopulmonary aspergillosis …

[HTML][HTML] The innate immune response to Aspergillus fumigatus

V Balloy, M Chignard - Microbes and infection, 2009 - Elsevier
Despite the development of new treatments, the mortality due to invasive pulmonary
aspergillosis remains above 50%, reaching 95% in certain situations. The battle against …

[HTML][HTML] Bronchial Epithelial Cells on the Front Line to Fight Lung Infection-Causing Aspergillus fumigatus

J Bigot, L Guillot, J Guitard, M Ruffin, H Corvol… - Frontiers in …, 2020 - frontiersin.org
Aspergillus fumigatus is an environmental filamentous fungus that can be pathogenic for
humans, wherein it is responsible for a large variety of clinical forms ranging from allergic …

[HTML][HTML] Role of Germination in Murine Airway CD8+ T-Cell Responses to Aspergillus Conidia

SP Templeton, AD Buskirk, B Law, BJ Green… - PloS one, 2011 - journals.plos.org
Pulmonary exposure to Aspergillus fumigatus has been associated with morbidity and
mortality, particularly in immunocompromised individuals. A. fumigatus conidia produce β …

[HTML][HTML] Dynamic Immune Cell Recruitment After Murine Pulmonary Aspergillus fumigatus Infection under Different Immunosuppressive Regimens

N Kalleda, J Amich, B Arslan, S Poreddy… - Frontiers in …, 2016 - frontiersin.org
Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus
fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently …