Chemopreventive or chemotherapeutic agents have been those that either kill cancer cells
to a differential degree over the non‐cancer cells or those chemicals that either block the …

To develop a strategy for efficacious intervention in order to prevent or treat various cancers,
one must understand the basic mechanism (s) by which various anticancer dietary factors …

The development of the most efficacious strategy for the prevention and treatment of cancers
is based on understanding the underlying mechanisms of carcinogenesis. This includes the …

Cells within a tissue continuously interact to coordinate normal tissue functions and maintain
homeostasis. Gap junctional communication (GJC), mediated by the connexin protein family …

Gap junctions, or connexons, are formed by connexin proteins and connect most cells in the
body to form water-filled channels directly linking the cytoplasm. Among the molecules …

In spite of the early speculation by Loewenstein that one of the critical distinguishing
phenotypes of cancers from normal cells was the dysfunction of gap junctional intercellular …

Understanding the process of carcinogenesis will involve both the accumulation of many
scientific facts derived from molecular, biochemical, cellular, physiological, whole animal …

Gap junctional intercellular communication plays a key role in the maintenance of
homeostasis in multicellular organisms. Reflecting deranged homeostasis in cancer cells …

Most, if not all, cancer cells have some dysfunction in gap-junction-mediated intercellular
communication, either because of defects in cell adhesion or inability to have functional gap …

Although the specific role of connexin-mediated gap junctional intercellular communication
in the control of cell homeostasis, proliferation, and death are still not clear, several lines of …