Autophagy in aging and longevity
SQ Wong, AV Kumar, J Mills, LR Lapierre - Human genetics, 2020 - Springer
Our understanding of the process of autophagy and its role in health and diseases has
grown remarkably in the last two decades. Early work established autophagy as a general …
grown remarkably in the last two decades. Early work established autophagy as a general …
Autophagy and the cell biology of age-related disease
Macroautophagy (autophagy) is a conserved lysosomal degradation process essential for
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …
cellular homeostasis and adaption to stress. Accumulating evidence indicates that …
Autophagy and aging
N Martinez-Lopez, D Athonvarangkul… - Longevity Genes: A …, 2015 - Springer
Autophagy is a critical quality control pathway that is conserved across diverse systems
ranging from simple unicellular organisms like yeast to more complex systems, for instance …
ranging from simple unicellular organisms like yeast to more complex systems, for instance …
Macroautophagy and aging: The impact of cellular recycling on health and longevity
JL Nieto-Torres, M Hansen - Molecular aspects of medicine, 2021 - Elsevier
Aging is associated with many deleterious changes at the cellular level, including the
accumulation of potentially toxic components that can have devastating effects on health. A …
accumulation of potentially toxic components that can have devastating effects on health. A …
Autophagy and the hallmarks of aging
Autophagy, an essential cellular process that mediates degradation of proteins and
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …
organelles in lysosomes, has been tightly linked to cellular quality control for its role as part …
Autophagy in healthy aging and disease
Autophagy is a fundamental cellular process that eliminates molecules and subcellular
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
elements, including nucleic acids, proteins, lipids and organelles, via lysosome-mediated …
How to live long and prosper: autophagy, mitochondria, and aging
WL Yen, DJ Klionsky - Physiology, 2008 - journals.physiology.org
Autophagy is a process of cellular self-degradation in which portions of the cytoplasm are
sequestered within cytosolic double-membrane vesicles and delivered to the …
sequestered within cytosolic double-membrane vesicles and delivered to the …
Autophagy in aging and in neurodegenerative disorders
YS Rajawat, I Bossis - Hormones, 2008 - Springer
Autophagy (ATG) is the process of bulk degradation and recycling of long-lived proteins,
macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis …
macromolecular aggregates, and damaged intracellular organelles. Cellular homeostasis …
How autophagy both activates and inhibits cellular senescence
C Kang, SJ Elledge - Autophagy, 2016 - Taylor & Francis
Autophagy and cellular senescence are stress responses essential for homeostasis. While
recent studies indicate a genetic relationship between autophagy and senescence, whether …
recent studies indicate a genetic relationship between autophagy and senescence, whether …
[HTML][HTML] Hallmarks of aging: an autophagic perspective
MC Barbosa, RA Grosso, CM Fader - Frontiers in endocrinology, 2019 - frontiersin.org
Autophagy is a major protein turnover pathway by which cellular components are delivered
into the lysosomes for degradation and recycling. This intracellular process is able to …
into the lysosomes for degradation and recycling. This intracellular process is able to …