The regulation of aging: does autophagy underlie longevity?

T Vellai, K Takács-Vellai, M Sass, DJ Klionsky - Trends in cell biology, 2009 - cell.com
The accumulation of cellular damage is a feature common to all aging cells and leads to
decreased ability of the organism to survive. The overall rate at which damage accumulates …

[图书][B] Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 12

MA Hayat - 2017 - books.google.com
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging,
Volume 12 discusses and details almost all aspects of the autophagy machinery in the …

Autophagy and human disease: emerging themes

JL Schneider, AM Cuervo - Current opinion in genetics & development, 2014 - Elsevier
Malfunction of autophagy, the process that mediates breakdown and recycling of
intracellular components in lysosomes, has been linked to a variety of human diseases. As …

Autophagy: supporting cellular and organismal homeostasis by self-eating

EL Eskelinen - The international journal of biochemistry & cell biology, 2019 - Elsevier
Autophagy is a conserved catabolic process that delivers cytoplasmic components and
organelles to lysosomes for degradation and recycling. This pathway serves to degrade …

Mechanism and medical implications of mammalian autophagy

I Dikic, Z Elazar - Nature reviews Molecular cell biology, 2018 - nature.com
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …

The role of autophagy in neurodegenerative disease

RA Nixon - Nature medicine, 2013 - nature.com
Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …

[HTML][HTML] Autophagy: for better or for worse

E Wirawan, TV Berghe, S Lippens, P Agostinis… - Cell research, 2012 - nature.com
Autophagy is a lysosomal degradation pathway that degrades damaged or superfluous cell
components into basic biomolecules, which are then recycled back into the cytosol. In this …

Autophagy: in sickness and in health

AM Cuervo - Trends in cell biology, 2004 - cell.com
The degradation of intracellular components in lysosomes (autophagy) has recaptured the
attention of cell biologists in recent years. The main reason for this renewed interest is the …

[HTML][HTML] Why is autophagy important in human diseases?

K Jing, K Lim - Experimental & molecular medicine, 2012 - nature.com
The process of macroautophagy (referred to hereafter as autophagy), is generally
characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past …

Autophagy: cellular and molecular mechanisms

D Glick, S Barth, KF Macleod - The Journal of pathology, 2010 - Wiley Online Library
Autophagy is a self‐degradative process that is important for balancing sources of energy at
critical times in development and in response to nutrient stress. Autophagy also plays a …