The regulation of aging: does autophagy underlie longevity?
T Vellai, K Takács-Vellai, M Sass, DJ Klionsky - Trends in cell biology, 2009 - cell.com
The accumulation of cellular damage is a feature common to all aging cells and leads to
decreased ability of the organism to survive. The overall rate at which damage accumulates …
decreased ability of the organism to survive. The overall rate at which damage accumulates …
[图书][B] Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging: Volume 12
MA Hayat - 2017 - books.google.com
Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging,
Volume 12 discusses and details almost all aspects of the autophagy machinery in the …
Volume 12 discusses and details almost all aspects of the autophagy machinery in the …
Autophagy and human disease: emerging themes
JL Schneider, AM Cuervo - Current opinion in genetics & development, 2014 - Elsevier
Malfunction of autophagy, the process that mediates breakdown and recycling of
intracellular components in lysosomes, has been linked to a variety of human diseases. As …
intracellular components in lysosomes, has been linked to a variety of human diseases. As …
Autophagy: supporting cellular and organismal homeostasis by self-eating
EL Eskelinen - The international journal of biochemistry & cell biology, 2019 - Elsevier
Autophagy is a conserved catabolic process that delivers cytoplasmic components and
organelles to lysosomes for degradation and recycling. This pathway serves to degrade …
organelles to lysosomes for degradation and recycling. This pathway serves to degrade …
Mechanism and medical implications of mammalian autophagy
Autophagy is a highly conserved catabolic process induced under various conditions of
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
cellular stress, which prevents cell damage and promotes survival in the event of energy or …
The role of autophagy in neurodegenerative disease
RA Nixon - Nature medicine, 2013 - nature.com
Autophagy is a lysosomal degradative process used to recycle obsolete cellular constituents
and eliminate damaged organelles and protein aggregates. These substrates reach …
and eliminate damaged organelles and protein aggregates. These substrates reach …
[HTML][HTML] Autophagy: for better or for worse
E Wirawan, TV Berghe, S Lippens, P Agostinis… - Cell research, 2012 - nature.com
Autophagy is a lysosomal degradation pathway that degrades damaged or superfluous cell
components into basic biomolecules, which are then recycled back into the cytosol. In this …
components into basic biomolecules, which are then recycled back into the cytosol. In this …
Autophagy: in sickness and in health
AM Cuervo - Trends in cell biology, 2004 - cell.com
The degradation of intracellular components in lysosomes (autophagy) has recaptured the
attention of cell biologists in recent years. The main reason for this renewed interest is the …
attention of cell biologists in recent years. The main reason for this renewed interest is the …
[HTML][HTML] Why is autophagy important in human diseases?
The process of macroautophagy (referred to hereafter as autophagy), is generally
characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past …
characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past …
Autophagy: cellular and molecular mechanisms
D Glick, S Barth, KF Macleod - The Journal of pathology, 2010 - Wiley Online Library
Autophagy is a self‐degradative process that is important for balancing sources of energy at
critical times in development and in response to nutrient stress. Autophagy also plays a …
critical times in development and in response to nutrient stress. Autophagy also plays a …