Degradation processes are important for optimal functioning of eukaryotic cells. The two
major protein degradation pathways in eukaryotes are the ubiquitin–proteasome pathway …

Autophagy, the process by which cells recycle cytoplasm and dispose of excess or defective
organelles, has entered the research spotlight largely owing to the discovery of the protein …

Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

Autophagy is an evolutionarily conserved cellular process in which macromolecules
undergo lysosomal degradation. It fulfills essential roles in quality controlling cellular …

Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to
the lysosome. Despite its simplicity, recent progress has demonstrated that autophagy plays …

As outlined in the accompanying Minireviews, autophagy is a complicated and highly
regulated process that delivers cellular material to lysosomes for degrading, recycling, and …

Autophagy and apoptosis are basic physiologic processes contributing to the maintenance
of cellular homeostasis. Autophagy encompasses pathways that target long-lived cytosolic …

Autophagy is an essential, conserved lysosomal degradation pathway that controls the
quality of the cytoplasm by eliminating protein aggregates and damaged organelles. It …

Autophagy is a lysosome-dependent cellular degradation program that responds to a variety
of environmental and cellular stresses. It is an evolutionarily well-conserved and essential …

Autophagy, a process of cellular self-digestion, delivers intracellular components including
superfluous and dysfunctional proteins and organelles to the lysosome for degradation and …