Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease

T Yasuhara, N Matsukawa, K Hara, G Yu… - Journal of …, 2006 - Soc Neuroscience
Neural stem cells (NSCs) possess high potencies of self-renewal and neuronal
differentiation. We explored here whether transplantation of human NSCs cloned by v-myc …

Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models …

SU Kim, IH Park, TH Kim, KS Kim, HB Choi… - …, 2006 - Wiley Online Library
Parkinson disease is a neurodegenerative disease characterized by loss of midbrain
dopaminergic neurons resulting in movement disorder. Neural stem cells (NSC) of the CNS …

Multiple neurogenic and neurorescue effects of human mesenchymal stem cell after transplantation in an experimental model of Parkinson's disease

L Cova, MT Armentero, E Zennaro, C Calzarossa… - Brain research, 2010 - Elsevier
Stimulation of endogenous repair in neurodegenerative diseases, such as Parkinson's
disease (PD), appears to be a novel and promising therapeutic application of stem cells …

[PDF][PDF] Human stem cell-derived neurons repair circuits and restore neural function

M Xiong, Y Tao, Q Gao, B Feng, W Yan, Y Zhou… - Cell Stem Cell, 2021 - cell.com
Although cell transplantation can rescue motor defects in Parkinson's disease (PD) models,
whether and how grafts functionally repair damaged neural circuitry in the adult brain is not …

[HTML][HTML] Intranigral transplantation of epigenetically induced BDNF-secreting human mesenchymal stem cells: implications for cell-based therapies in Parkinson's …

R Somoza, C Juri, M Baes, U Wyneken… - Biology of Blood and …, 2010 - Elsevier
It is thought that the ability of human mesenchymal stem cells (hMSC) to deliver neurotrophic
factors might be potentially useful for the treatment of neurodegenerative disorders. The aim …

Transplantation of human embryonic stem cell–derived neural progenitors improves behavioral deficit in parkinsonian rats

T Ben‐Hur, M Idelson, H Khaner, M Pera… - Stem …, 2004 - academic.oup.com
Human embryonic stem cells (hESCs) may potentially serve as a renewable source of cells
for transplantation. In Parkinson's disease, hESC‐derived dopaminergic (DA) neurons may …

Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat

M Yang, ND Stull, MA Berk, EY Snyder, L Iacovitti - Experimental neurology, 2002 - Elsevier
The ability to differentiate neural stem cells (NSCs) into dopamine neurons is fundamental to
their role in cell replacement therapies for neurodegenerative disorders such as Parkinson's …

[PDF][PDF] hESC-derived dopaminergic transplants integrate into basal ganglia circuitry in a preclinical model of Parkinson's disease

AF Adler, T Cardoso, S Nolbrant, B Mattsson… - Cell reports, 2019 - cell.com
Cell replacement is currently being explored as a therapeutic approach for
neurodegenerative disease. Using stem cells as a source, transplantable progenitors can …

Therapeutic effects of intranigral transplantation of mesenchymal stem cells in rat models of Parkinson's disease

D Chen, W Fu, W Zhuang, C Lv, F Li… - Journal of …, 2017 - Wiley Online Library
Stem cell transplantation is a promising tool for the treatment of neurodegenerative
disorders, including Parkinson's disease (PD); however, the therapeutic routes and …

Transplantation of neuronal-primed human bone marrow mesenchymal stem cells in hemiparkinsonian rodents

MLM Khoo, H Tao, ACB Meedeniya, A Mackay-Sim… - PloS one, 2011 - journals.plos.org
Bone marrow-derived human mesenchymal stem cells (hMSCs) have shown promise in in
vitro neuronal differentiation and in cellular therapy for neurodegenerative disorders …