From epigenetic associations to biological and psychosocial explanations in mental health

C Renzi, N Provencal, KC Bassil, K Evers… - Progress in Molecular …, 2018 - Elsevier
The development of mental disorders constitutes a complex phenomenon driven by unique
social, psychological and biological factors such as genetics and epigenetics, throughout an …

Contributions of epigenetic inheritance to the predisposition of major psychiatric disorders: Theoretical framework, evidence, and implications

RB Varela, JH Cararo, SJ Tye, AF Carvalho… - Neuroscience & …, 2022 - Elsevier
Susceptibility to psychiatric disorders seems to be influenced by environmental disturbances
throughout all stages of life. Epigenetics is described as a key “bridge” between gene and …

Etiology in psychiatry: embracing the reality of poly‐gene‐environmental causation of mental illness

R Uher, A Zwicker - World Psychiatry, 2017 - Wiley Online Library
Intriguing findings on genetic and environmental causation suggest a need to reframe the
etiology of mental disorders. Molecular genetics shows that thousands of common and rare …

Gene–environment interactions in common mental disorders: an update and strategy for a genome-wide search

R Uher - Social psychiatry and psychiatric epidemiology, 2014 - Springer
A decade of research has demonstrated the explanatory potential of interplay between
genetic variants and environmental factors in the development of common mental disorders …

[HTML][HTML] Genome–environment interactions and psychiatric disorders

J Peedicayil - Biomedicines, 2023 - mdpi.com
Environmental factors are known to interact with the genome by altering epigenetic
mechanisms regulating gene expression and contributing to the pathogenesis of psychiatric …

How does the social environment 'get into the mind'? Epigenetics at the intersection of social and psychiatric epidemiology

S Toyokawa, M Uddin, KC Koenen, S Galea - Social science & medicine, 2012 - Elsevier
The social environment plays a considerable role in determining major psychiatric disorders.
Emerging evidence suggests that features of the social environment modify gene expression …

Gene–environment interplay and psychopathology: Multiple varieties but real effects

M Rutter, TE Moffitt, A Caspi - Journal of child Psychology and …, 2006 - Wiley Online Library
Gene–environment interplay is a general term that covers several divergent concepts with
different meanings and different implications. In this review, we evaluate research evidence …

The epigenetics of social adversity in early life: implications for mental health outcomes

PO McGowan, M Szyf - Neurobiology of disease, 2010 - Elsevier
An organism's behavioral and physiological and social milieu influence and are influenced
by the epigenome, which is composed predominantly of chromatin and the covalent …

Gene–environment interaction

D Cicchetti - Development and Psychopathology, 2007 - cambridge.org
This Special Issue of Development and Psychopathology is devoted to the topic of gene–
environment interaction (G x E) and developmental psychopathology. GxE, one of several …

Gene–environment interactions in psychiatry: joining forces with neuroscience

A Caspi, TE Moffitt - Nature Reviews Neuroscience, 2006 - nature.com
Gene–environment interaction research in psychiatry is new, and is a natural ally of
neuroscience. Mental disorders have known environmental causes, but there is …