An association between the gene that codes for tryptophan hydroxylase (TPH)—the rate-
limiting enzyme in the synthesis of serotonin—and suicidal behavior has been investigated …

Tryptophan hydroxylase (TPH) is the rate-limiting enzyme of serotonin synthesis. In this case-
control study, we investigated whether the TPH gene was a susceptibility factor for suicidal …

According to WHO, suicide accounts for about 1 000 000 deaths worldwide every year. In
view of these dramatic data, several studies have tried to identify possible biological …

BACKGROUND: Tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of
serotonin, represents a major candidate in numerous genetic association analyses of …

Tryptophan hydroxylase (TPH), the enzyme controlling serotonin synthesis, is considered to
be a potential contributor to the biological substrate of suicide. The association of the …

Both environmental and genetic factors appear to contribute to the risk for suicide. The
serotonergic system has been implicated in depression, impulsivity and suicidality …

The association between suicide and a single nucleotide polymorphism (rs1386483) was
examined in the recently identified tryptophan hydroxylase 2 (TPH2) gene. Blood samples of …

Background: To determine whether the tryptophan hydroxylase gene (ie, the gene that
codes for the rate-limiting enzyme in the metabolic pathway of serotonin) may be a …

Findings relating serotonin to suicidal behavior suggest the role of genes for tryptophan
hydroxylase (TPH) in the genetic substrate of this disorder. Association of Tph1 gene and …

BACKGROUND: Neurobiological studies implicate serotonergic dysfunction in suicidal
behavior. Tryptophan hydroxylase (TPH), the rate-limiting enzyme in the biosynthesis of …