The mu-opioid receptor (MOR), a membrane-bound G protein-coupled receptor, is the main
target for opioids in the nervous system. MOR1 has been found in several types of cancer …

Preclinical evidence has shown increased expression of mu opioid receptor 1 (MOR-1) in
colorectal cancer although its association with disease-free and overall survival (DFS and …

Opioids are the most popular drugs for both acute and chronic pain management. The G
protein-coupled mu-opioid receptor (MOR) is the therapeutic target for most clinically used …

Aims In vitro and in vivo studies suggest that the mu-opioid receptor (MOR) is involved in
tumorigenesis, and metastasis in cancer. In humans, the use of MOR agonists (opioids) is …

Background We and others have previously demonstrated that the μ-opioid receptor (MOR)
is overexpressed in several human malignancies. There is a seven-fold increase in MOR in …

Opioid receptors, members of the G-protein–coupled receptor superfamily, appear to be
involved in cancer progression. However, the expression and significance of opioid …

Background Opioid receptors are implicated in cancer progression and long-term patient
outcomes. However, the prognostic significance, underlying mechanisms, and therapeutic …

Background Expression of the mu-opioid receptor (MOR) is associated with poor long-term
outcomes in various types of cancer. The association between MOR expression and clinical …

This study examined the presence and cellular localization of three types of opioid receptors
(MOR, DOR and KOR) in five human cancer cell lines: MCF-7, MDA-MB-231, HT-29, MGH …

Abstract Purpose of Review Opioids are still the most effective and widely used treatments
for acute and chronic pain in cancer patients. This review focuses on the impact of opioids …