Mortality remains very high among septic patients despite the advanced treatments
rendered in intensive care units. The development of septic shock is multifactorial. Tissue …

Although microbes and their associated toxins initiate sepsis, it is the subsequent host
inflammatory response that defines most of what we characterize as clinical sepsis. This …

Sepsis is the systematic response to infection. In septic patients who develop severe
disease, excessive inflammation damages the lungs, liver, kidneys, and cardiovascular …

Sepsis is a life-threatening medical condition that occurs when the host has an uncontrolled
or abnormal immune response to overwhelming infection. It is now widely accepted that …

Review on sepsis mediators, and roles in innate and adaptive immune systems, as well as
implications for therapeutics. Sepsis refers to severe systemic inflammation in response to …

Sepsis is a devastating and complex syndrome and continues to be a major cause of
morbidity and mortality among critically ill patients at the surgical intensive care unit setting …

Background: The past several years have seen remarkable advances in understanding the
basic cellular and physiologic mechanisms underlying organ dysfunction and recovery …

Sepsis and sepsis-associated multi-organ failure are major challenges for scientists and
clinicians and are a tremendous burden for health-care systems. Despite extensive basic …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

In cancer, therapies are targeted at 6 important pathways. In sepsis, there is ongoing
controversy regarding the number and relative roles of pathways that are activated or …