Most cell death stimuli trigger the mitochondrial release of cytochrome c and other cofactors
that induce caspase activation and ensuing apoptosis. Apoptosis is also associated with …

Mitochondrial fission facilitates cytochrome c release from the intracristae space into the
cytoplasm during intrinsic apoptosis, although how the mitochondrial fission factor Drp1 and …

In healthy cells, fusion and fission events participate in regulating mitochondrial morphology.
Disintegration of the mitochondrial reticulum into multiple punctiform organelles during …

Mitochondrial morphology within cells is controlled by precisely regulated rates of fusion and
fission [1–4]. During programmed cell death (PCD), mitochondria undergo extensive …

Mitochondria exist as a highly dynamic tubular network, and their morphology is governed
by the delicate balance between frequent fusion and fission events, as well as by …

During apoptosis mitochondria undergo cristae remodeling and fragmentation, but how the
latter relates to outer membrane permeabilization and downstream caspase activation is …

Dynamin-related protein 1 (DRP1) plays an important role in mitochondrial fission at steady
state and during apoptosis. Using fluorescence recovery after photobleaching, we …

DRP1, a member of the dynamin family of large GTPases, mediates mitochondrial fission. In
a recent issue of Developmental Cell, Cassidy-Stone et al.(2008) identified mdivi-1, a new …

Current research has demonstrated that mitochondrial morphology, distribution, and function
are maintained by the balanced regulation of mitochondrial fission and fusion, and …

Recent research has opened new avenues for the evaluation of mitochondrial function; for
example, mitochondria are no longer perceived as thread-like static entities within the …