Metabolomic profiling of the aqueous humor in patients with wet age-related macular degeneration using UHPLC–MS/MS

G Han, P Wei, M He, H Teng, Y Chu - Journal of proteome …, 2020 - ACS Publications
Assessing metabolomic alterations in age-related macular degeneration (AMD) can provide
insights into its pathogenesis. We compared the metabolomic profiles of the aqueous humor …

[HTML][HTML] Human plasma metabolomics in age-related macular degeneration: meta-analysis of two cohorts

I Laíns, W Chung, RS Kelly, J Gil, M Marques, P Barreto… - Metabolites, 2019 - mdpi.com
The pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness
worldwide, remains only partially understood. This has led to the current lack of accessible …

Human plasma metabolomics study across all stages of age-related macular degeneration identifies potential lipid biomarkers

I Laíns, RS Kelly, JB Miller, R Silva, DG Vavvas, IK Kim… - Ophthalmology, 2018 - Elsevier
Purpose To characterize the plasma metabolomic profile of patients with age-related
macular degeneration (AMD) using mass spectrometry (MS). Design Cross-sectional …

[HTML][HTML] Plasma metabolomic study in Chinese patients with wet age-related macular degeneration

D Luo, T Deng, W Yuan, H Deng, M Jin - BMC ophthalmology, 2017 - Springer
Background Age-related macular degeneration (AMD) is a leading disease associated with
blindness. It has a high incidence and complex pathogenesis. We aimed to study the …

Urine nuclear magnetic resonance (NMR) metabolomics in age-related macular degeneration

I Lains, D Duarte, AS Barros, AS Martins… - Journal of proteome …, 2019 - ACS Publications
Biofluid biomarkers of age-related macular degeneration (AMD) are still lacking, and their
identification is challenging. Metabolomics is well-suited to address this need, and urine is a …

[HTML][HTML] Untargeted metabolomics for uncovering plasma biological markers of wet age-related macular degeneration

Y Deng, P Shuai, H Wang, S Zhang, J Li, M Du… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Wet age-related macular degeneration (wAMD) causes central vision loss and represents a
major health problem in elderly people. Here we have used untargeted metabolomics using …

[HTML][HTML] Systemic and ocular fluid compounds as potential biomarkers in age-related macular degeneration

E Kersten, CC Paun, RL Schellevis, CB Hoyng… - survey of …, 2018 - Elsevier
Biomarkers can help unravel mechanisms of disease and identify new targets for therapy.
They can also be useful in clinical practice for monitoring disease progression, evaluation of …

[HTML][HTML] Plasma metabolomics of intermediate and neovascular age-related macular degeneration patients

SL Mitchell, C Ma, WK Scott, A Agarwal… - Cells, 2021 - mdpi.com
To characterize metabolites and metabolic pathways altered in intermediate and
neovascular age-related macular degeneration (IAMD and NVAMD), high resolution …

Serum metabolomics reveals personalized metabolic patterns for macular neovascular disease patient stratification

K Liu, J Fang, J Jin, S Zhu, X Xu, Y Xu… - Journal of proteome …, 2019 - ACS Publications
The macular neovascular disease is a group disorder with complex pathogenesis of
neovascularization for vision impairment and irreversible blindness, posing great challenges …

[HTML][HTML] Metabolomics in age-related macular degeneration: a systematic review

XW Hou, Y Wang, CW Pan - Investigative ophthalmology & …, 2020 - iovs.arvojournals.org
Purpose: Age-related macular degeneration (AMD) is one of the leading causes of
blindness among the elderly, and the exact pathogenesis of the AMD remains unclear. The …