Uncontrolled diabetes impairs muscle strength and mitochondrial metabolism, leading to
disabilities. FoxOs are key mediators of insulin signaling and we demonstrated that FoxOs …

Uncontrolled diabetes impairs muscle strength and mitochondrial metabolism, leading to
increased mortality. FoxOs are key mediators of insulin signaling and we demonstrated that …

Insulin deficiency and uncontrolled diabetes lead to a catabolic state with decreased muscle
strength, contributing to disease-related morbidity. FoxO transcription factors are suppressed …

Insulin and IGF-1, acting through the insulin receptor (IR) and IGF-1 receptor (IGF1R),
maintain muscle mass and mitochondrial function, at least part of which occurs via their …

Forkhead box protein O1 (FoxO1) regulates muscle growth, but the metabolic role of FoxO1
in skeletal muscle and its mechanisms remain unclear. To explore the metabolic role of …

Diabetes is associated with decreased muscle strength and energy production. There is a
strong association between muscle insulin resistance and mitochondrial abnormalities, but …

Background Muscle mitochondrial decline is associated with aging‐related muscle
weakness and insulin resistance. FoxO transcription factors are targets of insulin action and …

Forkhead box O (FoxO) proteins are transcription factors that mediate many aspects of
physiology and thus have been targeted as therapeutics for several diseases including …

Objective Gender influences obesity-related complications, including diabetes. Females are
more protected from insulin resistance after diet-induced obesity, which may be related to fat …

Decreased skeletal muscle strength and mitochondrial dysfunction are characteristic of
diabetes. The actions of insulin and IGF-1 through the insulin receptor (IR) and IGF-1 …