Cell senescence (CS) is at the nexus between aging and associated chronic disorders, and
aging increases the burden of CS in all major metabolic tissues. However, CS is also …

Abstract Purpose of Review Obesity has increased worldwide recently and represents a
major global health challenge. This review focuses on the obesity-associated cellular …

Increased insulin resistance and impaired insulin secretion are significant characteristics
manifested by patients with type 2 diabetes mellitus (T2DM). The degree and extent of these …

Adipose tissue inflammation and dysfunction are associated with obesity‐related insulin
resistance and diabetes, but mechanisms underlying this relationship are unclear. Although …

The growing burden of obesity-and aging-related diseases has hastened the search for
governing biological processes. Cellular senescence is a stress-induced state of stable …

In the last decades the prevalence of obesity has increased dramatically, and the worldwide
epidemic of obesity and related metabolic diseases has contributed to an increased interest …

Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular
mechanisms, one of which is cellular senescence. The abundance of senescent cells in …

Cell senescence is defined as a state of irreversible cell cycle arrest combined with DNA
damage and the induction of a senescence-associated secretory phenotype (SASP). This …

Cellular senescence is a cell fate that occurs in response to numerous types of stress and
can promote tissue repair or drive inflammation and disruption of tissue homeostasis …

Objective Cellular senescence, an irreversible proliferative cell arrest, is caused by
excessive intracellular or extracellular stress/damage. Increased senescent cells have been …