Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Aβ (1-42) accumulation

P Marsland, AS Vore, EM DaPrano, JM Paluch… - Alcohol, 2023 - Elsevier
Chronic alcohol consumption, Alzheimer's disease (AD), and vascular dementia are all
associated with cognitive decline later in life, raising questions about whether their …

A comparison of hippocampal microglial responses in aged and young rodents following dependent and non-dependent binge drinking

IR Grifasi, WA Evans, AD Rexha, LW Sako… - International review of …, 2019 - Elsevier
Alcoholism is a highly visible and prevalent issue in the United States. Although binge-
drinking is assumed to be a college-age problem, older adults (ages 65+) consume binge …

[HTML][HTML] Chronic ethanol causes persistent increases in Alzheimer's tau pathology in female 3xTg-AD mice: a potential role for lysosomal impairment

AE Tucker, CM Alicea Pauneto, AM Barnett… - Frontiers in Behavioral …, 2022 - frontiersin.org
Epidemiological studies have found that heavy alcohol use is associated with increased risk
for Alzheimer's disease (AD), with frequent drinking earlier in adulthood increasing risk. The …

Chronic intermittent ethanol exposure alters behavioral flexibility in aged rats compared to adult rats and modifies protein and protein pathways related to Alzheimer's …

AMC Ho, MP Peyton, SJ Scaletty, S Trapp… - ACS …, 2022 - ACS Publications
Repeated excessive alcohol consumption increases the risk of developing cognitive decline
and dementia. Hazardous drinking among older adults further increases such …

Preface: Setting the stage for understanding alcohol effects in late aging: A special issue including both human and rodent studies

T Deak, LM Savage - International review of neurobiology, 2019 - Elsevier
It is widely recognized that people worldwide are living longer than in previous decades,
with formidable projections regarding the expansion of elderly age groups in the decades to …

Aging with alcohol-related brain damage: Critical brain circuits associated with cognitive dysfunction

PT Nunes, BT Kipp, NL Reitz, LM Savage - International review of …, 2019 - Elsevier
Alcoholism is associated with brain damage and impaired cognitive functioning. The relative
contributions of different etiological factors, such as alcohol, thiamine deficiency and age …

[HTML][HTML] Ethanol exposure alters Alzheimer's-related pathology, behavior, and metabolism in APP/PS1 mice

SM Day, SC Gironda, CW Clarke, JA Snipes… - Neurobiology of …, 2023 - Elsevier
Epidemiological studies identified alcohol use disorder (AUD) as a risk factor for Alzheimer's
disease (AD), yet there is conflicting evidence on how alcohol use promotes AD pathology …

[HTML][HTML] Adolescent binge alcohol enhances early Alzheimer's disease pathology in adulthood through proinflammatory neuroimmune activation

A Barnett, E David, A Rohlman, VD Nikolova… - Frontiers in …, 2022 - frontiersin.org
Epidemiological studies suggest that heavy alcohol use early in life is associated with
increased risk for Alzheimer's disease (AD). However, mechanisms connecting AD with …

[HTML][HTML] Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study

JW Kim, MS Byun, D Yi, JH Lee, K Ko, SY Jeon… - PLoS …, 2020 - journals.plos.org
Background An emerging body of literature has indicated that moderate alcohol intake may
be protective against Alzheimer disease (AD) dementia. However, little information is …

Alcohol and Alzheimer's disease—does alcohol dependence contribute to beta-amyloid deposition, neuroinflammation and neurodegeneration in Alzheimer's disease …

A Venkataraman, N Kalk, G Sewell… - Alcohol and …, 2017 - academic.oup.com
Aims To investigate the underlying neurobiology between alcohol use, misuse and
dependence and cognitive impairment, particularly Alzheimer's disease (AD). Methods …