Transplantation of pancreatic islets encapsulated within immuno-protective microcapsules is
a strategy that has the potential to overcome graft rejection without the need for toxic …

Over the last decade, improvements in islet isolation techniques have made islet
transplantation an option for a certain subset of patients with long-standing diabetes …

Encapsulation of pancreatic islets has been proposed and investigated for over three
decades to improve islet transplantation outcomes and to eliminate the side effects of …

Transplantation of pancreatic islets in immune protective capsules holds the promise as a
functional cure for type 1 diabetes, also about 40 years after the first proof of principal study …

The transplantation of pancreatic islet cells could restore glycaemic control in patients with
type 1 diabetes. Microspheres for islet encapsulation have enabled long-term glycaemic …

Pancreatic islet transplantation improves metabolic control and prevents complications in
patients with brittle type 1 diabetes (T1D). However, chronic immunosuppression is required …

Encapsulating, or immunoisolating, insulin-secreting cells within implantable,
semipermeable membranes is an emerging treatment for type 1 diabetes. This approach …

Immune rejection following transplantation of non-encapsulated pancreatic islets has
remained a major obstacle to successful treatment of type I diabetes, despite the use of high …

Human islet transplantation can provide good glycemic control in diabetic recipients without
exogenous insulin. However, a major factor limiting its application is the recipient's need to …

Islet transplantation is a treatment modality for diabetes mellitus that can maintain insulin
levels within a physiologically appropriate range. However, wider clinical application is …